Post Cond No Reflow

This study has been completed.
Information provided by (Responsible Party):
Hospices Civils de Lyon Identifier:
First received: September 23, 2010
Last updated: May 7, 2013
Last verified: September 2010
After having shown that postconditioning allowed a significant 36% reduction of infarct size as assessed by blood levels of myocardial enzymes in acute myocardial patients, the investigators objective is to assess the effect of postconditioning in acute myocardial infarction (AMI) patients on microvascular obstruction lesions defined by cardiac MRI images.

Condition Intervention
Myocardial Reperfusion Injury
Procedure: postconditioning

Study Type: Interventional
Study Design: Allocation: Randomized
Endpoint Classification: Efficacy Study
Intervention Model: Parallel Assignment
Masking: Open Label
Primary Purpose: Treatment
Official Title: The POSTCONDITIONING and THE NO REFLOW Phenomenon in Acute Myocardial Infarction

Resource links provided by NLM:

Further study details as provided by Hospices Civils de Lyon:

Primary Outcome Measures:
  • Extent of the area of microvascular obstruction [ Time Frame: 5 days ] [ Designated as safety issue: Yes ]
    Extent of the area of microvascular obstruction defined on post-gadolinium CMR images realized 48-72 hours after admission in each group

Secondary Outcome Measures:
  • Size of the myocardial infarction [ Time Frame: 5 days ] [ Designated as safety issue: Yes ]
    Size of the myocardial infarction defined on post-gadolinium CMR images realized 48-72 hours after admission in each group.

Enrollment: 44
Study Start Date: April 2009
Study Completion Date: March 2011
Primary Completion Date: April 2009 (Final data collection date for primary outcome measure)
Arms Assigned Interventions
No Intervention: Control
22 controls patients without post conditionment
Experimental: Intervention
22 posconditioned patients
Procedure: postconditioning
Direct postconditioning (brief repeated cycle of 4 occlusion and desocclusion of the initially occluded culprit coronary artery) after primary direct stenting.


Ages Eligible for Study:   18 Years and older
Genders Eligible for Study:   Both
Accepts Healthy Volunteers:   No

Inclusion Criteria:

  • Patients > 18 years old,
  • Male or female,
  • Presenting first myocardial infarction, with the beginning of pains < 12 hours,
  • Requiring a revascularisation by primary angioplasty or " rescue " (after failure of thrombolysis) on IVA or RCA (not CA).
  • Artery guilty with TIMI flow = 0

Exclusion Criteria:

  • cardiac arrest before the angioplasty,
  • Cardiogenic shock
  • Occlusion of the artery circumflex responsible for the infarction
  • Magnetic resonance imaging: contre indication
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Please refer to this study by its identifier: NCT01208727

Hospices Civils de Lyon
Lyon, France
Sponsors and Collaborators
Hospices Civils de Lyon
Study Director: Pierre CROISILLE, MD Hospices Civils de Lyon
  More Information

Publications automatically indexed to this study by Identifier (NCT Number):
Responsible Party: Hospices Civils de Lyon Identifier: NCT01208727     History of Changes
Other Study ID Numbers: 2008-504 
Study First Received: September 23, 2010
Last Updated: May 7, 2013
Health Authority: France: Afssaps - Agence française de sécurité sanitaire des produits de santé (Saint-Denis)

Keywords provided by Hospices Civils de Lyon:
Myocardial infarction
Microvascular obstruction
No reflow

Additional relevant MeSH terms:
Myocardial Infarction
Myocardial Reperfusion Injury
Reperfusion Injury
Cardiovascular Diseases
Heart Diseases
Myocardial Ischemia
Pathologic Processes
Postoperative Complications
Vascular Diseases processed this record on May 26, 2016