Prognostic Biomarkers in Patients With Endometrial Cancer
Recruitment status was Not yet recruiting
RATIONALE: Studying samples of tissue from patients with cancer in the laboratory may help doctors learn more about changes that occur in DNA and identify biomarkers related to cancer.
PURPOSE: This research study is studying prognostic biomarkers in tissue samples from patients with endometrial cancer.
Genetic: DNA analysis
Genetic: mutation analysis
Other: laboratory biomarker analysis
|Official Title:||Validating the Prognostic Role of ATR Mutation in Patients With Endometrioid Endometrial Cancer|
- Overall survival [ Designated as safety issue: No ]
- Cancer-specific survival [ Designated as safety issue: No ]
- Disease-free survival [ Designated as safety issue: No ]
|Study Start Date:||October 2010|
|Estimated Primary Completion Date:||November 2010 (Final data collection date for primary outcome measure)|
- To validate the clinicopathologic associations and prognostic significance of ATR mutation in endometrioid endometrial cancer cases with defective DNA mismatch repair.
OUTLINE: This is a multicenter study.
DNA extracted from previously collected tumor samples is analyzed to validate the clinicopathologic associations and prognostic significance of ATR mutation.
Please refer to this study by its ClinicalTrials.gov identifier: NCT01208467
|Principal Investigator:||Israel Zighelboim, MD||Washington University Siteman Cancer Center|