MiRNAs Evaluate the Prognosis of Sepsis (METPS)

The recruitment status of this study is unknown because the information has not been verified recently.
Verified September 2010 by Chinese PLA General Hospital.
Recruitment status was  Recruiting
Information provided by:
Chinese PLA General Hospital
ClinicalTrials.gov Identifier:
First received: September 17, 2010
Last updated: September 22, 2010
Last verified: September 2010
Sepsis is a common cause of death in intensive care unit, timely and accurate diagnosis and treatment directly affect the survival rate. MiRNA is a post-transcriptional small RNA which regulate mRNA expression. The present study was designed to screen several miRNA by microarray which evaluate the sepsis prognosis in order to be a new target for the treatment of sepsis.


Study Type: Observational
Study Design: Observational Model: Case Control
Time Perspective: Prospective
Official Title: miRNA in the Evaluation of the Value of Sepsis Prognosis Prospective Observational Study

Resource links provided by NLM:

Further study details as provided by Chinese PLA General Hospital:

Primary Outcome Measures:
  • all cause mortality [ Time Frame: 28days after admited in ICU ] [ Designated as safety issue: No ]

Biospecimen Retention:   Samples Without DNA
human serum

Estimated Enrollment: 100
Study Start Date: July 2010
Estimated Study Completion Date: April 2011
Estimated Primary Completion Date: November 2010 (Final data collection date for primary outcome measure)
Survival Group
Death group

Detailed Description:
The study is a non-intervention, prospective observational study. Purpose of this sudy is to screening several miRNAs by microarray which can evaluate the prognosis of sepsis . We will collect serum samples from patients with sepsis in SICU, RICU and EICU of 301 Hospital since September 2009 , and then use the chip and qRT-PCR to Screen miRNAs which can evaluate the prognosis of sepsis, and statistical analysis the miRNAS expression correlation with SOFA score.

Ages Eligible for Study:   18 Years and older
Genders Eligible for Study:   Both
Accepts Healthy Volunteers:   Yes
Sampling Method:   Non-Probability Sample
Study Population
within 24 hours after admited in ICU

Inclusion Criteria:

  • Clinical diagnosis of sepsis
  • Patients who agree with the study

Exclusion Criteria:

  • Aged <18 years;
  • Into the group who died within 24 hours;
  • Agranulocytosis (<0.5 × 109 / L);
  • Combined HIV infection.
  Contacts and Locations
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Please refer to this study by its ClinicalTrials.gov identifier: NCT01207531

Contact: Huijuan Wang, master +86 13466791738 wanghuijuan301@gmail.com

China, Beijing
Chinese PLA General Hospital Recruiting
Beijing, Beijing, China, 100853
Sponsors and Collaborators
Chinese PLA General Hospital
Study Director: Lixin Xie, Doctor Pneumology Department of chinese PLA General Hospital
  More Information

Publications automatically indexed to this study by ClinicalTrials.gov Identifier (NCT Number):
Responsible Party: Lixin Xie, Pneumology Department of Chinese PLA General Hospital
ClinicalTrials.gov Identifier: NCT01207531     History of Changes
Other Study ID Numbers: 301PLAGH-2010915 
Study First Received: September 17, 2010
Last Updated: September 22, 2010
Health Authority: China: Ethics Committee

Keywords provided by Chinese PLA General Hospital:

Additional relevant MeSH terms:
Pathologic Processes
Systemic Inflammatory Response Syndrome

ClinicalTrials.gov processed this record on May 24, 2016