A Comparison of Cognitive and Dynamic Therapy for Depression in Community Settings
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|ClinicalTrials.gov Identifier: NCT01207271|
Recruitment Status : Completed
First Posted : September 22, 2010
Last Update Posted : May 2, 2017
The goal of this study is to compare supportive-expressive therapy, a type of psychodynamic psychotherapy, with cognitive therapy for the treatment of depression in community mental health consumers.
Hypothesized mediators of treatment will also be examined.
|Condition or disease||Intervention/treatment||Phase|
|Major Depressive Disorder||Behavioral: Cognitive Therapy Behavioral: Supportive-Expressive Psychodynamic Therapy||Not Applicable|
The goal of this study is to conduct a randomized, comparative, non-inferiority clinical trial that tests the hypothesis that a widely used form of manualized dynamic psychotherapy (supportive-expressive psychodynamic therapy) is not inferior to cognitive therapy when implemented in community mental health settings for the treatment of major depressive disorder (MDD). The specific aims are (1) to conduct a randomized non-inferiority trial to compare supportive-expressive psychodynamic therapy and cognitive therapy for patients with MDD and (2) to assess the comparative effectiveness of supportive-expressive psychodynamic therapy and cognitive therapy on secondary measures of symptoms, patient functioning, and quality of life.
Patient mediators of outcome will also be examined through an additional grant awarded to Paul Crits-Christoph, Ph.D. This grant was funded by the National Institutes of Mental Health - RO1MH092363-01. This grant is entitled:"The mechanisms of cognitive and dynamic therapy in community settings."
Recruitment will occur solely through community mental health clinics in and around Philadelphia.
|Study Type :||Interventional (Clinical Trial)|
|Actual Enrollment :||237 participants|
|Intervention Model:||Parallel Assignment|
|Masking:||None (Open Label)|
|Official Title:||A Comparison of Cognitive and Dynamic Therapy for MDD in Community Settings|
|Study Start Date :||November 2010|
|Actual Primary Completion Date :||December 9, 2014|
|Actual Study Completion Date :||December 9, 2014|
|Experimental: Cognitive Therapy||
Behavioral: Cognitive Therapy
16 sessions of cognitive therapy administered weekly by a community mental health therapist
|Experimental: Dynamic Therapy||
Behavioral: Supportive-Expressive Psychodynamic Therapy
16 sessions of supportive-expressive psychodynamic therapy administered weekly by a community mental health therapist
- Hamilton Rating Scale for Depression (HAM-D) [ Time Frame: 6 months ]
- BASIS-24 [ Time Frame: 6 months ]
- Beck Depression Inventory - II (BDI-II) [ Time Frame: 6 months ]
- Medical Outcomes Study 36-Item Short Form (SF-36) [ Time Frame: 6 months ]Measure of general functionality
- Quality of Life Inventory (QOLI) [ Time Frame: 6 months ]
- Ways of Responding (WOR) [ Time Frame: 2 months ]
- Dysfunctional Attitudes Scale (DAS) [ Time Frame: 2 months ]
- Psychological Distance Scaling Task (PDST) [ Time Frame: 2 months ]
- Self-Understanding of Interpersonal Patterns Scale-Revised (SUIP-R) [ Time Frame: 2 months ]
To learn more about this study, you or your doctor may contact the study research staff using the contact information provided by the sponsor.
Please refer to this study by its ClinicalTrials.gov identifier (NCT number): NCT01207271
|United States, Pennsylvania|
|University of Pennsylvania|
|Philadelphia, Pennsylvania, United States, 19104|
|Principal Investigator:||Mary Beth Gibbons, Ph.D.||University of Pennsylvania|
|Principal Investigator:||Paul Crits-Christoph, Ph.D.||University of Pennsylvania|