Treatment Of Bone Cyst With Bone Marrow Mesenchymal Cell Transplantation
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|ClinicalTrials.gov Identifier: NCT01207193|
Recruitment Status : Completed
First Posted : September 22, 2010
Last Update Posted : December 14, 2011
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There are two types of bone cysts, unicameral and aneurismal. These cysts happen to anyone, but they are most commonly seen in children and young adults while their bones are still growing. Living with a bone cyst and determining treatment options depend on the type of cyst.
Non-surgical treatments for unicameral bone cysts involves repeated X-rays in individuals who do not experience any symptoms.
Surgical removal of a unicameral bone cyst is needed if it becomes especially painful, or the area of the bone starts to thin out. The investigators aim to assess the clinical efficacy and side effects of mesenchymal stem cells seeded on bone matrix in repairing bone cyst.
|Condition or disease||Intervention/treatment||Phase|
|Bone Cyst||Biological: cell injection||Phase 1|
|Study Type :||Interventional (Clinical Trial)|
|Actual Enrollment :||6 participants|
|Intervention Model:||Single Group Assignment|
|Masking:||None (Open Label)|
|Official Title:||Effect of Bone Marrow-derived Mesenchymal Stem Cell Transplantation in Reconstructing Bone Defects.|
|Study Start Date :||October 2009|
|Actual Primary Completion Date :||October 2011|
|Actual Study Completion Date :||December 2011|
Experimental: bone cyst
Patients with bone cyst defect are injected with mesenchymal cells.
Biological: cell injection
injection of mesenchymal cells to bone cyst defect
Other Name: cell transplantation
- fulfill bone cyst defect [ Time Frame: 6 months ]Defect of bone due to cyst fulfill after cell transplantation.
- effect of mesenchymal cell transplantation [ Time Frame: 6 months ]Evaluate effect of mesenchymal cell transplantation to fulfill the defect of bone cyst.
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|Ages Eligible for Study:||12 Years to 75 Years (Child, Adult, Older Adult)|
|Sexes Eligible for Study:||All|
|Accepts Healthy Volunteers:||Yes|
- Bone cyst diagnosed with MRI, CT-scan, or X-Ray
- Intact cyst wall with high risk for fracture
- Cysts with minimum diameter of 6mm
- Diagnostic test performed on cyst fluid
- Provided written consent form
- Patients with diagnosis of cancer
- Patients enrolled in other clinical trial
To learn more about this study, you or your doctor may contact the study research staff using the contact information provided by the sponsor.
Please refer to this study by its ClinicalTrials.gov identifier (NCT number): NCT01207193
|Iran, Islamic Republic of|
|Tehran, Iran, Islamic Republic of|
|Study Chair:||Hamid Gourabi, PhD||President of Royan Institute|
|Study Director:||Mohammad reza Baghban Eslami Nejad, PhD||Scientific Board|
|Principal Investigator:||Mohssen Emadeddin, MD||Orthopedic Investigator|
|Study Director:||Ahmad Vosough, MD||Radiologist investigator|
|Principal Investigator:||Nasser Aghdami, MD,PhD||Head of regenerativ center|
|Responsible Party:||Hamid Gourabi/President of Royan Institute, Royan Institute|
|Other Study ID Numbers:||
|First Posted:||September 22, 2010 Key Record Dates|
|Last Update Posted:||December 14, 2011|
|Last Verified:||March 2009|
bone cyst bone defect mesenchymal cell