Immunological Changes Through Narrative Treatment of Post-Traumatic Stress Disorder (PTSD) in Torture Victims

The safety and scientific validity of this study is the responsibility of the study sponsor and investigators. Listing a study does not mean it has been evaluated by the U.S. Federal Government. Read our disclaimer for details. Identifier: NCT01206790
Recruitment Status : Completed
First Posted : September 22, 2010
Last Update Posted : February 22, 2012
German Research Foundation
Information provided by (Responsible Party):
Iris-Tatjana Kolassa, University of Ulm

Brief Summary:
Posttraumatic stress disorder (PTSD) is associated with poor health, high health care utilization, and an increased risk for a variety of somatic, inflammatory and autoimmune diseases. Research, including our own findings, indicates immunological alterations in PTSD patients. The aim of this study is to investigate whether alterations in the immune system of PTSD patients are reversible through a trauma-specific short-term therapy (Narrative Exposure Therapy).

Condition or disease Intervention/treatment Phase
PTSD Behavioral: NET Not Applicable

Study Type : Interventional  (Clinical Trial)
Actual Enrollment : 47 participants
Allocation: Randomized
Intervention Model: Parallel Assignment
Masking: Single (Outcomes Assessor)
Primary Purpose: Treatment
Official Title: Immunological Changes Through Narrative Treatment of PTSD in Torture Victims
Study Start Date : June 2009
Actual Primary Completion Date : May 2011
Actual Study Completion Date : January 2012

Resource links provided by the National Library of Medicine

U.S. FDA Resources

Arm Intervention/treatment
Experimental: Narrative Exposure Therapy (NET) Behavioral: NET
Narrative Exposure Therapy for traumatized survivors of organized violence
No Intervention: Waitinglist Control Group

Primary Outcome Measures :
  1. PTSD diagnosis and severity score according to the Clinicians Administered PTSD Scale (CAPS) [ Time Frame: 4 month after completion of treatment ]

Secondary Outcome Measures :
  1. changes in immunological parameters [ Time Frame: 4 months after completion of treatment ]

Information from the National Library of Medicine

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Ages Eligible for Study:   16 Years to 60 Years   (Child, Adult)
Sexes Eligible for Study:   All
Accepts Healthy Volunteers:   No

Inclusion Criteria:

  • PTSD diagnosis
  • experiences of organized violence/torture

Exclusion Criteria:

  • psychotic disorder
  • chronic inflammatory diseases

Information from the National Library of Medicine

To learn more about this study, you or your doctor may contact the study research staff using the contact information provided by the sponsor.

Please refer to this study by its identifier (NCT number): NCT01206790

University of Konstanz, Department of Psychology
Konstanz, Germany, 78467
Sponsors and Collaborators
University of Konstanz
German Research Foundation
Principal Investigator: Iris-Tatjana Kolassa, Prof. Dr. University of Ulm

Responsible Party: Iris-Tatjana Kolassa, Prof. Dr. Iris-Tatjana Kolassa, University of Ulm Identifier: NCT01206790     History of Changes
Other Study ID Numbers: NET-2010-KN
First Posted: September 22, 2010    Key Record Dates
Last Update Posted: February 22, 2012
Last Verified: February 2012

Keywords provided by Iris-Tatjana Kolassa, University of Ulm:
Narrative Exposure Therapy
torture victims
immune system

Additional relevant MeSH terms:
Stress Disorders, Post-Traumatic
Stress Disorders, Traumatic
Trauma and Stressor Related Disorders
Mental Disorders