Confocal Laser Micro-endoscopy in Chronic Obstructive Pulmonary Disease (COPD) and Lung Transplant Recipients
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|ClinicalTrials.gov Identifier: NCT01204970|
Recruitment Status : Completed
First Posted : September 20, 2010
Last Update Posted : December 30, 2016
|Condition or disease|
|Lung Transplantation Chronic Obstructive Pulmonary Disease|
In early phases of COPD, changes in small airway characteristics may develop. Elastin decay and matrix remodelling could be responsible for these changes. Using CLME changes of in the bronchiolar wall and alveolar ducts can be visualized, described and measured.
In lung transplant recipients, CMLE will be performed to distinguish characteristics of distal airways in stabile patient in contrast to patients with bronchiolitis obliterans syndrome.
In both groups data will be correlated with CT findings, pulmonary function tests and anatomopathological results.
|Study Type :||Observational|
|Actual Enrollment :||176 participants|
|Observational Model:||Case Control|
|Official Title:||Confocal Laser Micro-endoscopy: New Insights in COPD and Lung Transplant Recipients|
|Study Start Date :||September 2010|
|Actual Primary Completion Date :||July 2016|
|Actual Study Completion Date :||December 2016|
COPD Gold class 1-4
Lung transplant recipients
Patients with normal spirometric data
- morphometry [ Time Frame: 90 - 180 - 360 - 540 - 720 days ]morpohometrical analysis at different time point after lung transplantation
- adverse events [ Time Frame: 90 - 180 - 360- 540- 720 days ]bleeding, pneumothorax, pleuritic chest pain during procedure
To learn more about this study, you or your doctor may contact the study research staff using the contact information provided by the sponsor.
Please refer to this study by its ClinicalTrials.gov identifier (NCT number): NCT01204970
|University Hospitals Leuven|
|Leuven, Belgium, 3000|
|Principal Investigator:||Jonas Yserbyt, MD||University Hospitals Leuven|
|Principal Investigator:||Chistophe Dooms, MD, PhD||University Hospitals Leuven|
|Study Chair:||Marc Decramer, MD, PhD||University Hospitals Leuven|
|Study Chair:||Geert Verleden, Md, PhD||University Hospitals Leuven|
|Study Chair:||Wim Janssens, MD, PhD||University Hospitals Leuven|