Karolinska Cardiorenal Theme-centre and StockholmHeartbank (KKT)
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|ClinicalTrials.gov Identifier: NCT01204645|
Recruitment Status : Recruiting
First Posted : September 17, 2010
Last Update Posted : June 15, 2017
Chronic kidney disease (CKD) affects 10-18% of the adult population and is becoming recognized as one of the most serious disorders causing increased risk for cardiovascular disease and death. In patients with ischemic heart disease 26% have increased creatinine, which rises to 40% if patients also have diabetes mellitus. Risk increases as renal function diminishes, and just slowing the rate of decline in renal function would have a tremendous impact on health and morbidity. This association is commonly termed the Cardiorenal Syndrome, though it is caused by a much more complex interplay between major pathogenetic pathways such as glucose metabolism and diabetes, systemic and tissue inflammation, tissue metabolism, coagulation, mineral metabolism, sympathetic activation, renin-angiotensin-aldosterone system activation, endothelial dysfunction, lipid metabolism, fetal programming etc.
Karolinska Institutet recently merged basic and clinical researchers in all these fields, creating a Karolinska Kardiorenal Theme Centre; ultimately aiming to explore the syndrome and provide improved care for the individual patient.
The investigators road to success:
- Creating a Biobank (blood, DNA, plasma) from the majority of all hosptalized patients with ACS in Stockholm county - Stockholmheartbank.
- This Theme Center include all teaching hospitals associated with Karolinska Institutet; Danderyd University Hospital, Karolinska University Hospital and Södersjukhuset University Hospital. Together theses hospitals serve as emergency hospitals for 1.9 million people. The investigators are aiming at creating a biobank from all patients admitted for an acute coronary event (about 2.300/yr), which is a unique asset for molecular and genetic research as well as observational and intervention studies.
- The investigators have access to the National registry with 100% coverage, that contains data on all patients admitted to Stockholms coronary care units since 1995.
- To ensure translation in to clinical practice, most of the researchers are also MD:s, and several are clinically active.
- The clinical network facilitates the development of novel therapies and translational research.
- Steering groups for Education and a Clinical Practice implementation program.
|Condition or disease|
|Chronic Kidney Disease Chronic Renal Failure Acute Coronary Syndrome Ischemic Heart Disease Myocardial Infarction|
|Study Type :||Observational|
|Estimated Enrollment :||10000 participants|
|Official Title:||Stockholmheartbank and Karolinska Cardiorenal Theme-centre, From Genome to Clinical Practice in Patients With Acute Coronary Syndrome and Impaired Kidney Function|
|Study Start Date :||May 2010|
|Estimated Primary Completion Date :||May 2022|
|Estimated Study Completion Date :||January 2024|
Acute Coronary Syndrome (ACS)
Continuous inclusion at emergency hospitals of patients with acute coronary syndrome (according to ESC/AHA definitions)
Patients included at 6 or 12 months follow-up visit after an acute coronary event.
Patients included when undergoing an coronary angiography for suspected or confirmed coronary heart disease
- Composite [ Time Frame: 1 year ]Combined endpoint of death, new cardiovascular event or dialysis.
- Renal function decline [ Time Frame: 5 year ]
- Vascular function [ Time Frame: 1 year ]Vascular function assessed by arterial stiffness, microcirculation by Laser-Doppler
Biospecimen Retention: Samples With DNA
Please refer to this study by its ClinicalTrials.gov identifier (NCT number): NCT01204645
|Contact: Jonas Spaak, MD, PhD||+46 email@example.com|
|Danderyd University Hospital||Recruiting|
|Stockholm, Sweden, 18288|
|Contact: Jonas Spaak, MD, PhD +46 8 6557685 firstname.lastname@example.org|
|Study Director:||Jonas Spaak, MD PhD||Karolinska Institutet and Danderyd University Hospital|