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Testing the Effectiveness of a Computer-based Program for Depression

The safety and scientific validity of this study is the responsibility of the study sponsor and investigators. Listing a study does not mean it has been evaluated by the U.S. Federal Government. Read our disclaimer for details. Identifier: NCT01203683
Recruitment Status : Completed
First Posted : September 16, 2010
Last Update Posted : October 10, 2013
Information provided by (Responsible Party):
University of Texas at Austin

Brief Summary:
The purpose of this study is to determine whether completing a computer-based program alters changes how the brain processes emotional information and improves symptoms of depression.

Condition or disease Intervention/treatment Phase
Major Depressive Disorder Behavioral: Active computer-based training Behavioral: Inert computer training Phase 3

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Study Type : Interventional  (Clinical Trial)
Actual Enrollment : 53 participants
Allocation: Randomized
Intervention Model: Parallel Assignment
Masking: Triple (Participant, Investigator, Outcomes Assessor)
Primary Purpose: Treatment
Official Title: Attention Training for Major Depressive Disorder
Study Start Date : January 2011
Actual Primary Completion Date : October 2013
Actual Study Completion Date : October 2013

Resource links provided by the National Library of Medicine

Arm Intervention/treatment
Experimental: Active Computer-Based Program
Putatively therapeutic computer program.
Behavioral: Active computer-based training
8 sessions across 4 weeks.

Placebo Comparator: Placebo computer-based program
Inert computer program.
Behavioral: Inert computer training
8 sessions across 4 weeks.

Primary Outcome Measures :
  1. Beck Depression Inventory-II [ Time Frame: Week 4, Week 9 ]
    Questionnaire to assess depression symptom severity

Secondary Outcome Measures :
  1. Structured Clinical Interview for DSM-IV diagnoses [ Time Frame: Week 9 ]
    Diagnostic interview to assess for presence of Major depressive disorder (MDD).

  2. Neural processing of emotion stimuli [ Time Frame: Week 4 ]
    fMRI paradigm to assess neural changes in how individuals processes emotional stimuli

Information from the National Library of Medicine

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Ages Eligible for Study:   18 Years to 55 Years   (Adult)
Sexes Eligible for Study:   All
Accepts Healthy Volunteers:   No

Inclusion Criteria:

  • Major Depressive Disorder

Exclusion Criteria:

  • Substance dependence, psychotic disorder, bipolar disorder, schizophrenia, current psychotherapy, medications other than selective serotonin reuptake inhibitors

Information from the National Library of Medicine

To learn more about this study, you or your doctor may contact the study research staff using the contact information provided by the sponsor.

Please refer to this study by its identifier (NCT number): NCT01203683

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United States, Texas
University of Texas at Austin
Austin, Texas, United States, 78712
Sponsors and Collaborators
University of Texas at Austin
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Principal Investigator: Christopher Beevers, PhD University of Texas at Austin

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Responsible Party: University of Texas at Austin Identifier: NCT01203683     History of Changes
Other Study ID Numbers: 2010-09-0004
First Posted: September 16, 2010    Key Record Dates
Last Update Posted: October 10, 2013
Last Verified: October 2013

Keywords provided by University of Texas at Austin:

Additional relevant MeSH terms:
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Depressive Disorder
Depressive Disorder, Major
Mood Disorders
Mental Disorders
Behavioral Symptoms