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Testing the Effectiveness of a Computer-based Program for Depression

This study has been completed.
Information provided by (Responsible Party):
University of Texas at Austin Identifier:
First received: September 15, 2010
Last updated: October 9, 2013
Last verified: October 2013
The purpose of this study is to determine whether completing a computer-based program alters changes how the brain processes emotional information and improves symptoms of depression.

Condition Intervention Phase
Major Depressive Disorder Behavioral: Active computer-based training Behavioral: Inert computer training Phase 3

Study Type: Interventional
Study Design: Allocation: Randomized
Intervention Model: Parallel Assignment
Masking: Triple (Participant, Investigator, Outcomes Assessor)
Primary Purpose: Treatment
Official Title: Attention Training for Major Depressive Disorder

Further study details as provided by University of Texas at Austin:

Primary Outcome Measures:
  • Beck Depression Inventory-II [ Time Frame: Week 4, Week 9 ]
    Questionnaire to assess depression symptom severity

Secondary Outcome Measures:
  • Structured Clinical Interview for DSM-IV diagnoses [ Time Frame: Week 9 ]
    Diagnostic interview to assess for presence of Major depressive disorder (MDD).

  • Neural processing of emotion stimuli [ Time Frame: Week 4 ]
    fMRI paradigm to assess neural changes in how individuals processes emotional stimuli

Enrollment: 53
Study Start Date: January 2011
Study Completion Date: October 2013
Primary Completion Date: October 2013 (Final data collection date for primary outcome measure)
Arms Assigned Interventions
Experimental: Active Computer-Based Program
Putatively therapeutic computer program.
Behavioral: Active computer-based training
8 sessions across 4 weeks.
Placebo Comparator: Placebo computer-based program
Inert computer program.
Behavioral: Inert computer training
8 sessions across 4 weeks.


Ages Eligible for Study:   18 Years to 55 Years   (Adult)
Sexes Eligible for Study:   All
Accepts Healthy Volunteers:   No

Inclusion Criteria:

  • Major Depressive Disorder

Exclusion Criteria:

  • Substance dependence, psychotic disorder, bipolar disorder, schizophrenia, current psychotherapy, medications other than selective serotonin reuptake inhibitors
  Contacts and Locations
Choosing to participate in a study is an important personal decision. Talk with your doctor and family members or friends about deciding to join a study. To learn more about this study, you or your doctor may contact the study research staff using the Contacts provided below. For general information, see Learn About Clinical Studies.

Please refer to this study by its identifier: NCT01203683

United States, Texas
University of Texas at Austin
Austin, Texas, United States, 78712
Sponsors and Collaborators
University of Texas at Austin
Principal Investigator: Christopher Beevers, PhD University of Texas at Austin
  More Information

Responsible Party: University of Texas at Austin Identifier: NCT01203683     History of Changes
Other Study ID Numbers: 2010-09-0004
Study First Received: September 15, 2010
Last Updated: October 9, 2013

Keywords provided by University of Texas at Austin:

Additional relevant MeSH terms:
Depressive Disorder
Depressive Disorder, Major
Mood Disorders
Mental Disorders
Behavioral Symptoms processed this record on September 21, 2017