A Comparison of Desflurane vs. Sevoflurane and the Time to Awakening and the Incidence and Severity of Cough

The safety and scientific validity of this study is the responsibility of the study sponsor and investigators. Listing a study does not mean it has been evaluated by the U.S. Federal Government. Read our disclaimer for details. Identifier: NCT01202162
Recruitment Status : Completed
First Posted : September 15, 2010
Results First Posted : July 25, 2013
Last Update Posted : November 25, 2013
Information provided by (Responsible Party):
Gildasio De Oliveira, Northwestern University

Brief Summary:

Goals for ambulatory surgery include providing optimal surgical conditions while ensuring a rapid early recovery without side effect. Dexter et al1 concluded in a meta-analysis that Desflurane can reduce the extubation time when compared to Sevoflurane. This potential benefit of Desflurane can be especially attractive in short ambulatory cases performed with general anesthesia with a laryngeal mask airway.

Although some studies have not shown a difference on perioperative cough and laryngospasm between Desflurane and Sevoflurane at clinically relevant doses.It has been reported in the literature that Desflurane causes cough4 and many providers avoid using Desflurane with a LMA (laryngeal mask airway) in the ambulatory setting. In this study we will also evaluate, as a secondary outcome, the presence and severity of perioperative cough and laryngospasm.

Previous investigators have demonstrated a more rapid resumption of normal daily activities after ambulatory surgery in patients anesthetized with Desflurane when compared with Sevoflurane.these investigators suggested a better quality of recovery when Desflurane is used probably due to a lower lipid solubility of Desflurane. We will also evaluate quality of recovery as a secondary outcome using a validated instrument.


  1. A more rapid awakening, especially, in a fast and high turnover cases that are performed with LMA can lead to a more cost effective utilization of operating room time
  2. It has been reported that Desflurane causes more cough than Sevoflurane and Anesthesiologists avoid using Desflurane with LMA cases, this study will reinforce that there is no difference.

Condition or disease Intervention/treatment Phase
Surgery Anesthesia Drug: Desflurane Drug: Administration of Sevoflurane Not Applicable

Study Type : Interventional  (Clinical Trial)
Actual Enrollment : 85 participants
Allocation: Randomized
Intervention Model: Parallel Assignment
Masking: Double (Participant, Outcomes Assessor)
Official Title: A Comparison of Desflurane vs. Sevoflurane on Time to Awakening and the Incidence and Severity of Cough After Ambulatory Surgery Using Laryngeal Mask Airway
Study Start Date : February 2010
Actual Primary Completion Date : March 2012
Actual Study Completion Date : March 2012

Resource links provided by the National Library of Medicine

MedlinePlus related topics: Cough

Arm Intervention/treatment
Active Comparator: Desflurane
Administration of Desflurane
Drug: Desflurane
Administratino of Desflurane

Active Comparator: Sevoflurane
Administration of Sevoflurane
Drug: Administration of Sevoflurane
Administration of Sevoflurane

Primary Outcome Measures :
  1. Time to Awakening [ Time Frame: Time inhalational agent is turned off to time of patient awakening ]

Secondary Outcome Measures :
  1. Number of Participants Who Coughed [ Time Frame: Perioperative ]
  2. Quality of Recovery 40 [ Time Frame: 1 day ]
    Survey completion at 24 hours post surgery of the Quality of Recovery 40 questionnaire.This questionnaire asks 40 questions in 5 categories of recovery. The scores are combined from each group and are used as a composite score. The scores range from a low of 40 to a high of 200. A score of 40 would indicate a poor quality of recovery where as a score of 200 would be a good quality of recovery at 24 hours postoperative.

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Ages Eligible for Study:   18 Years to 65 Years   (Adult, Older Adult)
Sexes Eligible for Study:   All
Accepts Healthy Volunteers:   No

Inclusion Criteria:

  • Age 18-65
  • Female patients undergoing outpatient gynecologic and breast surgery
  • Under general anesthesia using an LMA
  • ASA I,II,

Exclusion Criteria:

  • Patients on CNS depressants
  • Chronic opioid use
  • Corticosteroid
  • Pregnant patients
  • Full stomach
  • Morbidly obese (BMI >35kg/m2)
  • Hepatitis B
  • Hepatitis C
  • Coronary artery disease
  • Liver disease
  • Renal disease
  • Seizure disorder

Dropout criteria:

  • Need for endotracheal tube
  • Surgeon or patient request
  • Hospital admission

Information from the National Library of Medicine

To learn more about this study, you or your doctor may contact the study research staff using the contact information provided by the sponsor.

Please refer to this study by its identifier (NCT number): NCT01202162

United States, Illinois
Northwestern University
Chicago, Illinois, United States, 60611
Sponsors and Collaborators
Northwestern University
Principal Investigator: Gildasio De Oliveira, M.D Northwestern University

Responsible Party: Gildasio De Oliveira, Principal Investigator, Northwestern University Identifier: NCT01202162     History of Changes
Other Study ID Numbers: STU00036200
First Posted: September 15, 2010    Key Record Dates
Results First Posted: July 25, 2013
Last Update Posted: November 25, 2013
Last Verified: October 2013

Keywords provided by Gildasio De Oliveira, Northwestern University:

Additional relevant MeSH terms:
Platelet Aggregation Inhibitors
Anesthetics, Inhalation
Anesthetics, General
Central Nervous System Depressants
Physiological Effects of Drugs