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Study of the Impact of Hypersplenism and Splenectomy on Hepatocarcinogenesis in Patients With Posthepatitic Cirrhosis

The recruitment status of this study is unknown. The completion date has passed and the status has not been verified in more than two years.
Verified January 2010 by Xijing Hospital.
Recruitment status was:  Recruiting
Fourth Military Medical University
Health Science Center of Xi’an Jiaotong University
Information provided by:
Xijing Hospital Identifier:
First received: September 13, 2010
Last updated: NA
Last verified: January 2010
History: No changes posted
The purpose of this study is to investigate the impact of splenectomy coupled with portal-azygous disconnection on hepatocarcinogenesis in patients with post-hepatitic cirrhosis after hepatitis B or C virus infection by retrospective case-control study,We hope to find a new idear and method to prevent or cure HCC.

Liver Cirrhosis
Carcinoma, Hepatocellular

Study Type: Observational
Study Design: Observational Model: Case Control
Time Perspective: Retrospective
Official Title: Multicentric Retrospective Case Control Study of the Impact of Hypersplenism and Splenectomy on Hepatocarcinogenesis in Patients With Posthepatitic Cirrhosis

Resource links provided by NLM:

Further study details as provided by Xijing Hospital:

Estimated Enrollment: 5000
Study Start Date: January 2010
Estimated Study Completion Date: December 2012
Estimated Primary Completion Date: December 2012 (Final data collection date for primary outcome measure)
Detailed Description:
A case-control study was carried out. The factors studied include age, gender, ascites, hepatic encephalopathy, ALT, AST, TBIL, ALP, GGT, Child-Pugh classification of liver function, and history of splenectomy with portal-azygous disconnection during the treatment of portal hypertension. According to the Child-Pugh classification, these cases were graded as A, B, and C. And according to the ranges of the normal reference values of the data, they were categorized into two groups including a normal group and an abnormal group.The data mainly comes from FMMU and Xi'an jiaotong university from the year of 2002 to 2012.

Ages Eligible for Study:   20 Years to 90 Years   (Adult, Senior)
Sexes Eligible for Study:   All
Accepts Healthy Volunteers:   No
Sampling Method:   Probability Sample
Study Population
post-hepatitic cirrhosis with portal hypertension and hypersplenism patients

Inclusion Criteria:

  • after surgery

Exclusion Criteria:

  • without surgery
  Contacts and Locations
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Please refer to this study by its identifier: NCT01201655

Contact: Chen yong, professor 13891915509

China, Shaanxi
Chen yong Recruiting
Xi'an, Shaanxi, China, 710032
Contact: Chen yong, professor    13891915509   
Sub-Investigator: Li zhe, professor         
Sponsors and Collaborators
Xijing Hospital
Fourth Military Medical University
Health Science Center of Xi’an Jiaotong University
Study Director: Chen yong, professor Xia jielai
  More Information

Responsible Party: chen yong, Xijing Hospital Identifier: NCT01201655     History of Changes
Other Study ID Numbers: chenyong
Study First Received: September 13, 2010
Last Updated: September 13, 2010

Keywords provided by Xijing Hospital:
Posthepatitic cirrhosis;

Additional relevant MeSH terms:
Liver Cirrhosis
Carcinoma, Hepatocellular
Pathologic Processes
Liver Diseases
Digestive System Diseases
Neoplasms, Glandular and Epithelial
Neoplasms by Histologic Type
Liver Neoplasms
Digestive System Neoplasms
Neoplasms by Site
Pathological Conditions, Anatomical
Splenic Diseases
Lymphatic Diseases processed this record on May 24, 2017