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DPBRN Retrospective Cohort Study of Osteonecrosis of the Jaw

This study has been completed.
HealthPartners Institute
Kaiser Permanente
Permanente Dental Associates Group, Oregon
National Institute of Dental and Craniofacial Research (NIDCR)
Information provided by:
Dental Practice-Based Research Network Identifier:
First received: September 13, 2010
Last updated: June 14, 2011
Last verified: June 2011
The purpose of this study was to determine the prevalence of ONJ in the patient population of 2 large HMOs and study the risk factors associated with the development of this condition.

Osteonecrosis of the Jaw

Study Type: Observational
Study Design: Observational Model: Cohort
Time Perspective: Retrospective
Official Title: Retrospective Cohort Study of ONJ

Resource links provided by NLM:

Further study details as provided by Dental Practice-Based Research Network:

Enrollment: 572606
Study Start Date: January 2007
Study Completion Date: May 2008
Primary Completion Date: May 2008 (Final data collection date for primary outcome measure)
ONJ sufferers
history of jaw osteonecrosis
Bisphosphonate exposure
patients with exposure to bisphosphonates

Detailed Description:
The electronic database from Kaiser Permanente and HealthParnters of Minnesota were used to identify all ONJ cases that occured between 1994 and 2006 and then demographic, social and medical risk factors possibly associated with the disease were abstracted and analyzed.

Ages Eligible for Study:   41 Years and older   (Adult, Senior)
Sexes Eligible for Study:   All
Accepts Healthy Volunteers:   Yes
Sampling Method:   Non-Probability Sample
Study Population
All patients older than 40 with a history of jaw osteonecrosis and control patients with exposure to biphosphonates were included.

Inclusion Criteria:

  • ONJ sufferers and control biphosphonate users older than 40, of any gender, race and ethnic origin
  Contacts and Locations
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Please refer to this study by its identifier: NCT01201330

United States, Alabama
Gregg H. Gilbert, DDS, MBA
Birmingham, Alabama, United States, 35294-0007
Sponsors and Collaborators
Dental Practice-Based Research Network
HealthPartners Institute
Kaiser Permanente
Permanente Dental Associates Group, Oregon
National Institute of Dental and Craniofacial Research (NIDCR)
Principal Investigator: Jeffrey Fellows, Ph.D. Kaiser Permanente
Principal Investigator: Andrei Barasch, DMD,MDSc University of Alabama at Birmingham
Principal Investigator: Brad Rindal, DMD HealthPartners of Minnesota
Study Chair: Gregg H Gilbert, DDS, MBA University of Alabama School of Dentistry
  More Information

Responsible Party: Gregg H. Gilbert, DDS, MBA, Study Chair, University of Alabama at Birmingham Identifier: NCT01201330     History of Changes
Other Study ID Numbers: 106030
U01DE016747 ( US NIH Grant/Contract Award Number )
Study First Received: September 13, 2010
Last Updated: June 14, 2011

Keywords provided by Dental Practice-Based Research Network:

Additional relevant MeSH terms:
Bone Diseases
Musculoskeletal Diseases
Pathologic Processes processed this record on May 25, 2017