Try our beta test site
IMPORTANT: Listing of a study on this site does not reflect endorsement by the National Institutes of Health. Talk with a trusted healthcare professional before volunteering for a study. Read more...

POCD in Elderly Patients Following Desflurane or Sevoflurane General Anesthesia

This study has been completed.
Information provided by (Responsible Party):
Richard Applegate, Loma Linda University Identifier:
First received: September 9, 2010
Last updated: September 8, 2014
Last verified: September 2014
The use of desflurane in elderly subjects (>65 years old) undergoing general anesthesia with endotracheal intubation will result in decreased POCD compared to sevoflurane if the patient's MAP is within 20% of the patient's baseline and the cerebral suppression state index stays within the moderately anesthetized range during general anesthesia.

Condition Intervention
1. Postoperative Cognitive Dysfunction
Other: The intervention will be Mini-Mental Status Examination (MMSE)

Study Type: Observational
Study Design: Observational Model: Case Control
Time Perspective: Prospective
Official Title: Incidence of Postoperative Cognitive Dysfunction in Elderly Patients Following Desflurane or Sevoflurane General Anesthesia: A Randomized, Controlled Trial

Resource links provided by NLM:

Further study details as provided by Loma Linda University:

Primary Outcome Measures:
  • POCD in Elderly Patients Following Desflurane or Sevoflurane General Anesthesia [ Time Frame: Both groups will complete the MMSE at 1, 6, and 24 hours after the end of anesthesia or to disharge up to 7 days. ]
    The primary outcome measure will be changes in cognitive function after anesthesia as measured by MMSE.

Secondary Outcome Measures:
  • Secondary outcome measures will include: 1) time to extubation, anesthetic complications (e.g. coughing during extubation), 2) time to readiness for discharge from PACU, 3) length of hospital stay, and 4) any postoperative complications. [ Time Frame: 24 hours to 7 days ]

Enrollment: 110
Study Start Date: August 2010
Study Completion Date: August 2014
Primary Completion Date: August 2014 (Final data collection date for primary outcome measure)
Groups/Cohorts Assigned Interventions
desflurane and sevoflurane
Subjects will be randomized to either desflurane or sevoflurane. They will be given the Mini Mental State exam at 1, 6 and 24 hours after the end of anesthesia.
Other: The intervention will be Mini-Mental Status Examination (MMSE)
A questionnaire given to the study patient before and after the anesthetic at 1, 6 and 24 hours.


Ages Eligible for Study:   65 Years and older   (Adult, Senior)
Sexes Eligible for Study:   All
Accepts Healthy Volunteers:   No
Sampling Method:   Non-Probability Sample
Study Population
Adult patients, male and female, 65 years or older scheduled for elective surgery requiring general anesthesia.

Inclusion Criteria:

  • Adult patients (>65 years old)
  • Scheduled for elective surgery requiring general anesthesia at LLUMC HSH
  • Airway management expected to include endotracheal intubation
  • Expected surgical duration 120 to 240 minutes

Exclusion Criteria:

  • Pre-existing significant psychiatric disease or mental status changes
  • Clinically significant cardiovascular, respiratory, hepatic, renal,neurological, psychiatric, or metabolic disease
  • Patient's weighing >50% ideal body weight

    • Men: Ideal Body Weight (in kilograms) = 50 + 2.3 kg per inch over 5 feet
    • Women: Ideal Body Weight (in kilograms) = 45.5 + 2.3kg per inch over 5 feet
  • Patients who have undergone a general anesthetic within the past 7 days
  • Patient refusal
  Contacts and Locations
Choosing to participate in a study is an important personal decision. Talk with your doctor and family members or friends about deciding to join a study. To learn more about this study, you or your doctor may contact the study research staff using the Contacts provided below. For general information, see Learn About Clinical Studies.

Please refer to this study by its identifier: NCT01199913

United States, California
Loma Linda University
Loma Linda, California, United States, 92354
Sponsors and Collaborators
Loma Linda University
  More Information

Publications automatically indexed to this study by Identifier (NCT Number):
Responsible Party: Richard Applegate, MD, Loma Linda University Identifier: NCT01199913     History of Changes
Other Study ID Numbers: 5100193
Study First Received: September 9, 2010
Last Updated: September 8, 2014

Keywords provided by Loma Linda University:
problems with thinking after surgery;

Additional relevant MeSH terms:
Cognition Disorders
Neurocognitive Disorders
Mental Disorders
Central Nervous System Depressants
Physiological Effects of Drugs
Anesthetics, Inhalation
Anesthetics, General
Platelet Aggregation Inhibitors processed this record on May 25, 2017