Association Between Fractional Exhaled Nitric Oxide and Asthma Control (FeNO_AS)

The safety and scientific validity of this study is the responsibility of the study sponsor and investigators. Listing a study does not mean it has been evaluated by the U.S. Federal Government. Read our disclaimer for details. Identifier: NCT01197690
Recruitment Status : Completed
First Posted : September 9, 2010
Last Update Posted : September 18, 2015
Information provided by (Responsible Party):
Nualanong Visitsunthorn, Mahidol University

Brief Summary:
The purpose of this study is to determine mean or median of fractional exhaled nitric oxide (FeNO) in Thai atopic asthmatic patients that divided into subgroups due to level of asthma control according to the global initiative for asthma guideline.

Condition or disease
Bronchial Asthma

Detailed Description:

From many previous studies, fractional exhaled nitric oxide (FeNO) has many benefits such as non-invasive, easily to perform, less time consume, has direct association with severity of inflammation of bronchial trees and sputum eosinophils, has benefit for diagnosis and monitoring the treatment in asthmatic patients.

In Thailand, this field of study is less extend, especially in children population. We hypothesized that in uncontrolled or partly controlled group may have high level of fractional exhaled nitric oxide (FeNO) than controlled group.

It is therefore desirable to examine the association between fractional exhaled nitric oxide (FeNO) and level of asthma control among atopic asthmatic Thai children and will be the main objective of this research.

Study Type : Observational
Actual Enrollment : 62 participants
Observational Model: Case Control
Time Perspective: Cross-Sectional
Official Title: Association Between Fractional Exhaled Nitric Oxide and Asthma Control
Study Start Date : February 2010
Actual Primary Completion Date : December 2010
Actual Study Completion Date : December 2010

Resource links provided by the National Library of Medicine

MedlinePlus related topics: Asthma

Primary Outcome Measures :
  1. fractional exhaled nitric oxide level [ Time Frame: 10 minutes (average time), on the day of enrollment ]

Secondary Outcome Measures :
  1. scores of asthma control test: ACT [ Time Frame: 5 minutes (average time), on the day of enrollment ]

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Ages Eligible for Study:   7 Years to 60 Years   (Child, Adult)
Sexes Eligible for Study:   All
Accepts Healthy Volunteers:   No
Sampling Method:   Non-Probability Sample
Study Population
atopic asthmatic patients in Department of Pediatrics, Siriraj hospital (tertiary care)

Inclusion Criteria:

  • clinical diagnosis of atopic bronchial asthma
  • follow up in clinic of allergy and clinical immunology, Siriraj hospital

Exclusion Criteria:

  • smoker or past history of smoking
  • has chronic disease eg. HIV infection, pulmonary hypertension, systemic lupus erythematosus, liver cirrhosis, gastroesophageal reflux, COPD, bronchiectasis
  • drink ethanol within 48 hours before enrollment
  • history of upper or lower respiratory tract infection within 6 weeks before enrollment
  • drink caffeine within day before enrollment
  • during pregnancy
  • history of systemic steroid use within 8 weeks before enrollment

Information from the National Library of Medicine

To learn more about this study, you or your doctor may contact the study research staff using the contact information provided by the sponsor.

Please refer to this study by its identifier (NCT number): NCT01197690

Siriraj Hospital
Bangkok, Thailand
Sponsors and Collaborators
Mahidol University
Principal Investigator: Professor Nualanong Visitsunthorn, MD Department of Pediatrics, Faculty of Medicine Siriraj Hospital, Mahidol University

Responsible Party: Nualanong Visitsunthorn, Professor, Mahidol University Identifier: NCT01197690     History of Changes
Other Study ID Numbers: 602/2552(EC1)
First Posted: September 9, 2010    Key Record Dates
Last Update Posted: September 18, 2015
Last Verified: September 2015

Keywords provided by Nualanong Visitsunthorn, Mahidol University:
Bronchial asthma
level of control of asthma
fractional exhaled nitric oxide (FeNO)
asthma control test (ACT)

Additional relevant MeSH terms:
Bronchial Diseases
Respiratory Tract Diseases
Lung Diseases, Obstructive
Lung Diseases
Respiratory Hypersensitivity
Hypersensitivity, Immediate
Immune System Diseases
Nitric Oxide
Bronchodilator Agents
Autonomic Agents
Peripheral Nervous System Agents
Physiological Effects of Drugs
Anti-Asthmatic Agents
Respiratory System Agents
Free Radical Scavengers
Molecular Mechanisms of Pharmacological Action
Neurotransmitter Agents
Endothelium-Dependent Relaxing Factors
Vasodilator Agents
Protective Agents