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Thoracic Outlet Syndrome: Case Reports and Analysis With Ultrasound Imaging

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ClinicalTrials.gov Identifier: NCT01196637
Recruitment Status : Completed
First Posted : September 8, 2010
Last Update Posted : September 9, 2010
Information provided by:
EMG Labs of Arizona Arthritis & Rheumatology Associates

Brief Summary:
Thoracic outlet syndrome is caused by compression of the brachial plexus, in most cases under the pectoralis minor muscle in the infraclavicular region of the shoulder. The hypothesis is that ultrasound imaging can be used to visualize brachial plexus compression and distortion of the pectoralis muscle during arm activity, such as abduction, and that normal subjects will not demonstrate any plexus compression or muscle distortion.

Condition or disease
Thoracic Outlet Syndrome

Detailed Description:
Four patients with thoracic outlet syndrome (TOS) underwent clinical exam and nerve testing to prove that they had TOS and no other nerve abnormality. They subsequently had ultrasound imaging of the shoulder (infraclavicular region) at rest and during arm abduction stress testing. Two control subjects had similar clinical exams and nerve testing to prove they did not have TOS, and then underwent similar ultrasound stress testing. The TOS patients demonstrated brachial plexus compression and pectoralis minor muscle distortion during the stress tests, and the normal subjects showed no plexus compression or muscle distortion.

Study Type : Observational
Actual Enrollment : 6 participants
Observational Model: Case Control
Time Perspective: Prospective
Official Title: Thoracic Outlet Syndrome: Case Reports and Analysis - Ultrasound Imaging and Pathomechanics of Brachial Plexus Compression
Study Start Date : June 2010
Primary Completion Date : September 2010
Study Completion Date : September 2010

Thoracic outlet syndrome
These patients have documented thoracic outlet syndrome
Normal Subjects
These patients have no thoracic outlet syndrome

Primary Outcome Measures :
  1. Brachial plexus compression on ultrasound imaging in thoracic outlet syndrome patients [ Time Frame: 4 months ]

Secondary Outcome Measures :
  1. No brachial plexus compression in normal subjects [ Time Frame: 4 months ]

Information from the National Library of Medicine

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Ages Eligible for Study:   18 Years to 70 Years   (Adult, Senior)
Sexes Eligible for Study:   All
Accepts Healthy Volunteers:   Yes
Sampling Method:   Non-Probability Sample
Study Population
Adult patients with upper limb symptoms of pain, numbness, tingling, or weakness, aggravated by arm abduction; Adult patients with no upper limb symptoms


Thoracic outlet patients must have:

  • symptoms consistent with thoracic outlet syndrome, and
  • no electrical testing abnormality, and
  • positive arm abduction stress tests.

Normal subjects must have:

  • no upper limb symptoms, or
  • normal nerve testing, and
  • negative arm abduction stress test


Thoracic outlet patients excluded if they have:

  • nerve test abnormalities, or
  • negative arm abduction stress test

Normals excluded if they have:

  • abnormalities on nerve testing, or
  • positive arm abduction stress tests

Information from the National Library of Medicine

To learn more about this study, you or your doctor may contact the study research staff using the contact information provided by the sponsor.

Please refer to this study by its ClinicalTrials.gov identifier (NCT number): NCT01196637

United States, Arizona
EMG Labs of AARA
Paradise Valley, Arizona, United States, 85253
Sponsors and Collaborators
EMG Labs of Arizona Arthritis & Rheumatology Associates
Principal Investigator: Benjamin M Sucher, D.O. EMG Labs of AARA

Responsible Party: Benjamin M. Sucher, D.O. / Medical Director, EMG Labs of AARA
ClinicalTrials.gov Identifier: NCT01196637     History of Changes
Other Study ID Numbers: TOS-US BP JAOA
First Posted: September 8, 2010    Key Record Dates
Last Update Posted: September 9, 2010
Last Verified: September 2010

Keywords provided by EMG Labs of Arizona Arthritis & Rheumatology Associates:
thoracic outlet syndrome
brachial plexopathy

Additional relevant MeSH terms:
Thoracic Outlet Syndrome
Pathologic Processes
Nerve Compression Syndromes
Peripheral Nervous System Diseases
Neuromuscular Diseases
Nervous System Diseases
Vascular Diseases
Cardiovascular Diseases