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ClinicalTrials.gov Identifier: NCT01193959
Verified September 2010 by Istituto Clinico Humanitas. Recruitment status was: Active, not recruiting
Present study is aimed at investigating potential molecular predictors of sensitivity or resistance to single-agent pemetrexed in the ≥ second line setting in a large cohort of advanced non-small cell lung cancer (NSCLC) patients. The following biomarkers will be investigated with either immunohistochemistry, fluorescence in situ hybridization or genotyping: thymidylate synthase (TS), dihydrofolate reductase (DHFR), glycinamide ribonucleotide formyl transferase (GARFT), aminoimidazole carboxamide ribonucleotide formyltransferase (ATIC/AICARFT), epidermal growth factor receptor (EGFR), Kirsten rat sarcoma 2 viral oncogene homolog (KRAS), v-myc myelocytomatosis viral oncogene homolog (MYC) and phosphoinositide-3-kinase, catalytic, alpha polypeptide (PIK3CA).
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Ages Eligible for Study:
18 Years and older (Adult, Senior)
Sexes Eligible for Study:
Accepts Healthy Volunteers:
Non-small cell lung cancer patients treated with single agent pemetrexed
Histologically confirmed diagnosis of advanced non-small cell lung cancer - Tumor tissue available at our institution
Patients treated with single agent pemetrexed for metastatic disease
Availability of full clinical data
Cytological diagnosis of advanced Non-small cell lung cancer