fMRI Cholinergic Mechanisms in Schizophrenia
This study aims to determine how clozapine treatment improves neuronal measures of sensory gating in subjects with schizophrenia.
|Study Design:||Observational Model: Cohort
Time Perspective: Cross-Sectional
|Official Title:||fMRI Cholinergic Mechanisms in Schizophrenia|
- Neuronal Response During Sensory Gating [ Time Frame: Immediate ] [ Designated as safety issue: No ]Neuronal response (blood oxygenation level dependent functional magnetic resonance imaging signal, relative to the global mean) during sensory gating. Sensory gating is defined as the process of filtering out unnecessary environmental stimuli.
|Study Start Date:||October 2008|
|Study Completion Date:||December 2011|
|Primary Completion Date:||December 2011 (Final data collection date for primary outcome measure)|
Patients with schizophrenia treated with clozapine
This study will use functional magnetic resonance imaging (fMRI) to study patients treated with risperidone, a commonly used neuroleptic that does not improves sensory gating, to those treated with clozapine to determine which brain areas are involved in clozapine's normalization of sensory gating in schizophrenia.
Please refer to this study by its ClinicalTrials.gov identifier: NCT01191827
|United States, Colorado|
|VA Eastern Colorado Health Care System, Denver|
|Denver, Colorado, United States, 80220|
|Principal Investigator:||Jason R. Tregellas, PhD||VA Eastern Colorado Health Care System, Denver|