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Progesterone Rise in Agonist Versus Antagonist in Vitro Fertilization (IVF) Cycles

The recruitment status of this study is unknown. The completion date has passed and the status has not been verified in more than two years.
Verified January 2009 by Universitair Ziekenhuis Brussel.
Recruitment status was:  Active, not recruiting
Information provided by:
Universitair Ziekenhuis Brussel Identifier:
First received: August 27, 2010
Last updated: September 14, 2010
Last verified: January 2009
The aim is to explore whether the incidence of progesterone rise in the late follicular phase differs between GnRH-agonist and GnRH-antagonist protocols for IVF and whether this has an impact on the probability of pregnancy achievement.

Condition Intervention Phase
Pregnancy Outcome After In Vitro Fertilization (IVF)
Other: In vitro fertilization
Phase 4

Study Type: Interventional
Study Design: Allocation: Randomized
Intervention Model: Parallel Assignment
Masking: Open Label
Primary Purpose: Treatment
Official Title: Is the Clinical Outcome Affected by the Incidence of Progesterone Elevation on the Day of hCG Triggering When Agonist Protocol is Compared to Antagonist Protocol for IVF

Resource links provided by NLM:

Further study details as provided by Universitair Ziekenhuis Brussel:

Primary Outcome Measures:
  • Incidence of late progesterone rise on the day of HCG triggering [ Time Frame: Up to delivery (2010) ]

Secondary Outcome Measures:
  • Clinical pregnancy rate Delivery rate [ Time Frame: Up to delivery (2010) ]

Enrollment: 200
Study Start Date: January 2007
Estimated Study Completion Date: January 2011
Estimated Primary Completion Date: January 2011 (Final data collection date for primary outcome measure)
Arms Assigned Interventions
Experimental: Antagonist group
Antagonist protocol for IVF
Other: In vitro fertilization
In vitro fertilization procedure with gonadotropin induced follicular ovarian stimulation
Other Names:
  • IVF
  • pregnancy
  • embryo-transfer
  • progesterone
Active Comparator: Agonist group
Long Agonist protocol for IVF
Other: In vitro fertilization
In vitro fertilization procedure with gonadotropin induced follicular ovarian stimulation
Other Names:
  • IVF
  • pregnancy
  • embryo-transfer
  • progesterone

Detailed Description:
In view of the current debate concerning possible differences in efficacy between the two GnRH analogues, the current study aimed to explore whether progesterone control in the late follicular phase differs when GnRH-agonist is used as compared to GnRH-antagonist and if so to what extend does the progesterone rise have an impact on the probability of achieving a pregnancy.

Ages Eligible for Study:   21 Years to 39 Years   (Adult)
Sexes Eligible for Study:   Female
Accepts Healthy Volunteers:   No

Inclusion Criteria:

  • age < 39
  • follicle-stimulating hormone (FSH) < 12
  • gonadotropin dose 100-300IU

Exclusion Criteria:

  • endometriosis
  • known endocrine disorder
  • blood analyzed in another laboratory
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Please refer to this study by its identifier: NCT01191710

Thessaloniki, Pylaia, Greece, 55536
Sponsors and Collaborators
Universitair Ziekenhuis Brussel
Study Chair: Basil Tarlatzis, MD BioGenesis
  More Information

Additional Information:
Publications automatically indexed to this study by Identifier (NCT Number):
Responsible Party: Papanikolaou Evangelos, Human Reproduction and Genetics Foundation (HRG) Identifier: NCT01191710     History of Changes
Other Study ID Numbers: ProgRise001
Study First Received: August 27, 2010
Last Updated: September 14, 2010

Keywords provided by Universitair Ziekenhuis Brussel:

Additional relevant MeSH terms:
Hormones, Hormone Substitutes, and Hormone Antagonists
Physiological Effects of Drugs processed this record on April 28, 2017