Radiation Planning Study for High Grade Brain Tumors

The safety and scientific validity of this study is the responsibility of the study sponsor and investigators. Listing a study does not mean it has been evaluated by the U.S. Federal Government. Read our disclaimer for details. Identifier: NCT01191346
Recruitment Status : Completed
First Posted : August 30, 2010
Last Update Posted : August 22, 2017
Information provided by (Responsible Party):
Alison Kastl, BS, CCRC, University of Cincinnati

Brief Summary:
The purpose of this research study is to see if a higher strength MRI procedure provides better images to use in planning radiation treatments for patients with brain tumors in the future.

Condition or disease Intervention/treatment
High Grade Glioma Other: 3T MRI

Study Type : Observational
Actual Enrollment : 24 participants
Observational Model: Case-Only
Time Perspective: Prospective
Official Title: 3T Versus 1.5T MR Approaches in Target Definition for Malignant Gliomas: Is There a Significant Difference in Tumor Extent and Radiation Treatment Volume?
Study Start Date : June 2010
Actual Primary Completion Date : March 2013
Actual Study Completion Date : March 2013

Resource links provided by the National Library of Medicine

Group/Cohort Intervention/treatment
Patients receiving 3T MRI
Other: 3T MRI
3T MRI in addition to standard 1.5T MRI for treatment planning

Primary Outcome Measures :
  1. Treatment volume [ Time Frame: 1 year average ]
    To assess the difference in treatment volume for radiation planning in gliomas as calculated using 1.5T versus 3T magnets

Information from the National Library of Medicine

Choosing to participate in a study is an important personal decision. Talk with your doctor and family members or friends about deciding to join a study. To learn more about this study, you or your doctor may contact the study research staff using the contacts provided below. For general information, Learn About Clinical Studies.

Ages Eligible for Study:   18 Years and older   (Adult, Older Adult)
Sexes Eligible for Study:   All
Accepts Healthy Volunteers:   No
Sampling Method:   Non-Probability Sample
Study Population
Patients with high grade glioma planning to receive radiation therapy

Inclusion Criteria:

  • Histologically confirmed, newly diagnosed Grade III-IV glioma
  • Planning to undergo radiation therapy

Exclusion Criteria:

  • Grade I or II glioma
  • Patients unable to undergo MRI imaging

Information from the National Library of Medicine

To learn more about this study, you or your doctor may contact the study research staff using the contact information provided by the sponsor.

Please refer to this study by its identifier (NCT number): NCT01191346

United States, Ohio
University of Cincinnati
Cincinnati, Ohio, United States, 45219
Sponsors and Collaborators
University of Cincinnati
Principal Investigator: Jessica Guarnaschelli, MD University of Cincinnati

Responsible Party: Alison Kastl, BS, CCRC, Director of Clinical Trials, University of Cincinnati Identifier: NCT01191346     History of Changes
Other Study ID Numbers: BTC-G1
First Posted: August 30, 2010    Key Record Dates
Last Update Posted: August 22, 2017
Last Verified: December 2014
Individual Participant Data (IPD) Sharing Statement:
Plan to Share IPD: No

Additional relevant MeSH terms:
Neoplasms, Neuroepithelial
Neuroectodermal Tumors
Neoplasms, Germ Cell and Embryonal
Neoplasms by Histologic Type
Neoplasms, Glandular and Epithelial
Neoplasms, Nerve Tissue