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Treatment for Young Adults With Anorexia Nervosa

This study has been completed.
ClinicalTrials.gov Identifier:
First Posted: August 27, 2010
Last Update Posted: August 26, 2016
The safety and scientific validity of this study is the responsibility of the study sponsor and investigators. Listing a study does not mean it has been evaluated by the U.S. Federal Government. Read our disclaimer for details.
National Institute of Mental Health (NIMH)
Information provided by (Responsible Party):
Temple University
Temple University is conducting a National Institute of Health funded research study designed to develop and refine a family-based treatment manual for young adults with Anorexia Nervosa as well as assess the feasibility of this out-patient psychotherapy.

Condition Intervention Phase
Anorexia Nervosa Behavioral: Out-Patient Psychotherapy Treatment Phase 1 Phase 2

Study Type: Interventional
Study Design: Allocation: Non-Randomized
Intervention Model: Single Group Assignment
Masking: None (Open Label)
Primary Purpose: Treatment
Official Title: Family-Based Treatment for Weight Restoration in Young Adults With Anorexia Nervosa

Further study details as provided by Temple University:

Primary Outcome Measures:
  • Weight (BMI) [ Time Frame: 6 months of treatment ]

Secondary Outcome Measures:
  • Changes in shape and weight concerns as measured with Eating Disorder Examination subscales [ Time Frame: 18 therapy sessions or 6 months of treatment ]

Estimated Enrollment: 30
Study Start Date: July 2010
Study Completion Date: April 2016
Primary Completion Date: April 2016 (Final data collection date for primary outcome measure)
Arms Assigned Interventions
Experimental: Family Based Treatment Behavioral: Out-Patient Psychotherapy Treatment
Individual and Group Therapy Sessions
Other Names:
  • FBT
  • FBT-Y

Detailed Description:

Anorexia Nervosa (AN) is a serious psychiatric illness that occurs in an estimated 0.5 to 3.7% of women. The illness severely affects physical, emotional, and social functioning. The mortality rates associated with this severely disabling condition are higher than those for any other psychiatric disorder and substantially higher than those expected in the general population. Lower weight at presentation, longer illness duration, and alcohol abuse are associated with a higher risk of mortality.

Treatment-outcome for adult AN is poor with a quarter of adults with AN having poor outcome. In AN, promising outcomes are seen in family-based treatment (FBT) for adolescent patients who present between the ages of 12 to 18 with a short duration of illness. A manualized version of FBT has now been tested in several studies and case series, showing that well over 80% of participants had good or intermediate outcome at post-treatment. Despite its efficacy with adolescents, FBT has not been utilized with young adults.

The purpose of this study is to develop and refine FBT to promote weight gain in young adults with Anorexia Nervosa.


Information from the National Library of Medicine

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Ages Eligible for Study:   18 Years to 30 Years   (Adult)
Sexes Eligible for Study:   All
Accepts Healthy Volunteers:   No

Inclusion Criteria:

  • Meet DSM-IV criteria for AN (restricting/binge-purge type) (BMI 16.0-18.5)
  • Medically stable for outpatient treatment
  • Availability of at least one supportive adult of choice in study client's environment
  • Stable dose of psychotropic medication (8 weeks) for co-morbid condition

Exclusion Criteria:

  • Associated physical illness that necessitates hospitalization
  • Psychotic illness or other mental illness requiring hospitalization
  • Current dependence on drugs or alcohol
  • Physical conditions (e.g. diabetes mellitus, pregnancy) known to influence eating or weight
  • Previous Family-Based Treatment for Anorexia
  Contacts and Locations
Information from the National Library of Medicine

To learn more about this study, you or your doctor may contact the study research staff using the contact information provided by the sponsor.

Please refer to this study by its ClinicalTrials.gov identifier (NCT number): NCT01190423

United States, Pennsylvania
Temple University
Philadelphia, Pennsylvania, United States, 19122
Sponsors and Collaborators
Temple University
National Institute of Mental Health (NIMH)
Principal Investigator: Eunice Y Chen, PhD Temple University
  More Information

Additional Information:
Responsible Party: Temple University
ClinicalTrials.gov Identifier: NCT01190423     History of Changes
Other Study ID Numbers: 20550
R34MH083914-01 ( U.S. NIH Grant/Contract )
First Submitted: August 25, 2010
First Posted: August 27, 2010
Last Update Posted: August 26, 2016
Last Verified: August 2016

Keywords provided by Temple University:

Additional relevant MeSH terms:
Anorexia Nervosa
Signs and Symptoms, Digestive
Signs and Symptoms
Feeding and Eating Disorders
Mental Disorders