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Study: Effects of Strawberries on Blood Pressure (CSCBP)

The recruitment status of this study is unknown. The completion date has passed and the status has not been verified in more than two years.
Verified May 2012 by University of California, Davis.
Recruitment status was:  Active, not recruiting
California Strawberry Commission
Information provided by (Responsible Party):
University of California, Davis Identifier:
First received: October 20, 2009
Last updated: May 1, 2012
Last verified: May 2012
The specific aim of the study is to determine whether a freeze dried powder provided by the California Strawberries Commission, can reduce blood pressure in patients with pre-hypertension. The powder is prepared by the California Strawberry Commission (CSC).

Condition Intervention
Pre-hypertension Other: Strawberry Beverage Other: Placebo

Study Type: Interventional
Study Design: Allocation: Randomized
Intervention Model: Parallel Assignment
Masking: Double Blind (Participant, Investigator)
Primary Purpose: Basic Science
Official Title: Effect of Strawberry Powder on Blood Pressure in Individuals With Pre-Hypertension

Further study details as provided by University of California, Davis:

Primary Outcome Measures:
  • Change in blood pressure [ Time Frame: 8 weeks ]

Secondary Outcome Measures:
  • Change in low density lipoprotein (LDL) oxidation [ Time Frame: 8 weeks ]
  • Change in flow mediated dilation (FMD) [ Time Frame: 8 weeks ]

Estimated Enrollment: 50
Study Start Date: September 2007
Estimated Study Completion Date: May 2012
Primary Completion Date: October 2011 (Final data collection date for primary outcome measure)
Arms Assigned Interventions
Placebo Comparator: Placebo Beverage
The placebo beverage is matched in energy, macronutrient composition and sensory properties to the active beverage, but is devoid of strawberry polyphenols.
Other: Placebo
Placebo beverage, 8 weeks
Other Name: Beverage
Experimental: Strawberry Beverage
The strawberry beverage is matched in energy, macronutrient composition and sensory properties to the placebo beverage, but contains strawberry polyphenols.
Other: Strawberry Beverage
Beverage, daily for 8 weeks, 12g freeze-dried strawberry powder
Other Name: Strawberry powder made from a mix of California strawberries.

Detailed Description:
Primarily, we would like to find out whether freeze dried strawberry powder lowers blood pressure. In addition we would like to know if the strawberry alters the subject's blood cholesterol and the ability of the subject's blood vessels to relax.

Ages Eligible for Study:   25 Years to 65 Years   (Adult)
Sexes Eligible for Study:   All
Accepts Healthy Volunteers:   No

Inclusion Criteria:

  • Pre-hypertensive men and women (JNC 7 [The Seventh Report of the Joint National Committee on Prevention, Detection, Evaluation, and Treatment of High Blood Pressure] criteria) between the ages of 25 and 65 years who have no clinical evidence/history of cardiovascular, respiratory, renal, gastrointestinal or hepatic disease.

Exclusion Criteria:

  • Subjects who:

    1. are taking over the counter anti-oxidant supplements,
    2. are taking prescription medications that may interfere with study procedures or endpoints,
    3. have unusual dietary habits (eg., pica),
    4. are actively losing weight or trying to lose weight,
    5. are addicted to drugs or alcohol,
    6. present with significant psychiatric or neurological disturbances,
    7. have known allergies to strawberry, will be excluded from participating in this study.
    8. Patients known to have glaucoma
    9. Pregnant and/or lactating females
  Contacts and Locations
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Please refer to this study by its identifier: NCT01190319

United States, California
University of California Davis (Ragle Hall)
Davis, California, United States, 95616
Sponsors and Collaborators
University of California, Davis
California Strawberry Commission
Principal Investigator: Chulani T Kappagoda, MD University of California, Davis
Principal Investigator: Britt Burton-Freeman, Ph.D University of California, Davis
  More Information

Responsible Party: University of California, Davis Identifier: NCT01190319     History of Changes
Other Study ID Numbers: 200715153
Study First Received: October 20, 2009
Last Updated: May 1, 2012

Keywords provided by University of California, Davis:
blood pressure
fruit phenolics
LDL oxidation
Flow mediated dilation (FMD)

Additional relevant MeSH terms:
Vascular Diseases
Cardiovascular Diseases processed this record on June 23, 2017