Levothyroxine (L-T4) Absorption After Bariatric Surgery (RYS)
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ClinicalTrials.gov Identifier: NCT01189344 |
Recruitment Status :
Completed
First Posted : August 26, 2010
Last Update Posted : August 26, 2010
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Condition or disease | Intervention/treatment | Phase |
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Morbid Obesity | Drug: Levothyroxine | Not Applicable |

Study Type : | Interventional (Clinical Trial) |
Actual Enrollment : | 30 participants |
Intervention Model: | Parallel Assignment |
Masking: | None (Open Label) |
Primary Purpose: | Basic Science |
Official Title: | Levothyroxine Absorption in Morbidly Obese Patients Before and After Roux-en-Y Bariatric Surgery |
Study Start Date : | September 2007 |
Actual Primary Completion Date : | July 2010 |
Actual Study Completion Date : | July 2010 |

Arm | Intervention/treatment |
---|---|
Experimental: Not surgical group
The Nos surgical (NS) group includes 15 patients for whom bariatric surgery is planned. Body mass index (BMI) of this group of patients is ≥40 Kg/m2.
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Drug: Levothyroxine
600 µg of oral levothyroxine(LT4. Blood samples were collected before and after LT4 administration |
Experimental: Surgical group
The Surgical (S) group includes 15 patients who had undergone Roux-en-Y bariatric surgery 2 to 3 months before inclusion in the study
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Drug: Levothyroxine
600 µg of oral levothyroxine(LT4. Blood samples were collected before and after LT4 administration |

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Ages Eligible for Study: | 18 Years and older (Adult, Older Adult) |
Sexes Eligible for Study: | All |
Accepts Healthy Volunteers: | No |
Inclusion Criteria:
- morbidly obese individual (body mass index (BMI)≥40 Kg/m2)
- individuals for whom bariatric surgery is indicated
- patients who had undergone Roux-en-Y bariatric surgery 2 to 3 months before inclusion in the study
Exclusion Criteria:
- previous diagnosis of thyroid cancer
- diabetes mellitus in use of insulin
- chronic or atrophic gastritis
- use of medications associated with impaired LT4 absorption.

To learn more about this study, you or your doctor may contact the study research staff using the contact information provided by the sponsor.
Please refer to this study by its ClinicalTrials.gov identifier (NCT number): NCT01189344
Brazil | |
Hospital das Clínicas da Universidade de São Paulo | |
São Paulo, Brazil |
Responsible Party: | Geraldo Medeiros-Neto, University of São Paulo Medical School |
ClinicalTrials.gov Identifier: | NCT01189344 |
Other Study ID Numbers: |
1039/07 |
First Posted: | August 26, 2010 Key Record Dates |
Last Update Posted: | August 26, 2010 |
Last Verified: | June 2007 |
Obesity LT4 Absorption Thyroid function |
Obesity, Morbid Obesity Overnutrition |
Nutrition Disorders Overweight Body Weight |