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Efficacy of Methylsulfonylmethane Supplementation on Osteoarthritis of The Knee: A Randomized Controlled Study

This study has been completed.
ClinicalTrials.gov Identifier:
First Posted: August 25, 2010
Last Update Posted: August 25, 2010
The safety and scientific validity of this study is the responsibility of the study sponsor and investigators. Listing a study does not mean it has been evaluated by the U.S. Federal Government. Read our disclaimer for details.
Information provided by:
Assaf-Harofeh Medical Center
The aim of this study was to determine the efficacy of methylsulfonylmethane (MSM) in treating patients with knee OA.

Condition Intervention
Knee Osteoarthritis Dietary Supplement: Methylsulfonylmethane (MSM)

Study Type: Interventional

Resource links provided by NLM:

Further study details as provided by Assaf-Harofeh Medical Center:

Primary Outcome Measures:
  • WOMAC questionnaire

Arms Assigned Interventions
Experimental: Purified MSM Dietary Supplement: Methylsulfonylmethane (MSM)


Information from the National Library of Medicine

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Ages Eligible for Study:   40 Years to 70 Years   (Adult, Senior)
Sexes Eligible for Study:   All

Inclusion Criteria:

  • symptomatic knee OA for at least 6 months according to the clinical criteria of the American College of Rheumatology (ACR)
  • radiographic confirmed knee OA according to the Kellgren & Lawrence scale

Exclusion Criteria:

  • acute septic arthritis
  • inflammatory arthritis
  • any other type of arthritis
  • history of knee buckling or recent knee injury
  • lack of physical or mental bility to perform or comply with the treatment procedure
  • diabetes mellitus
  • fibromyalgia or other chronic pain syndromes
  • concurrent anti-coagulant/anti-platelet drugs
  • arthroscopy or intra-articular injections in the previous 3 months
  Contacts and Locations
No Contacts or Locations Provided
  More Information

Publications automatically indexed to this study by ClinicalTrials.gov Identifier (NCT Number):
ClinicalTrials.gov Identifier: NCT01188213     History of Changes
Other Study ID Numbers: 13/05
First Submitted: August 21, 2010
First Posted: August 25, 2010
Last Update Posted: August 25, 2010
Last Verified: May 2005

Additional relevant MeSH terms:
Osteoarthritis, Knee
Joint Diseases
Musculoskeletal Diseases
Rheumatic Diseases
Dimethyl sulfone
Dimethyl Sulfoxide
Anti-Inflammatory Agents
Cryoprotective Agents
Protective Agents
Physiological Effects of Drugs
Free Radical Scavengers
Molecular Mechanisms of Pharmacological Action