Study of Tocotrienol Absorption and Distribution Under Different Fat Status
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ClinicalTrials.gov Identifier: NCT01185769 |
Recruitment Status :
Completed
First Posted : August 20, 2010
Last Update Posted : August 20, 2010
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Condition or disease | Intervention/treatment | Phase |
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Absorption | Dietary Supplement: Tocotrienol | Not Applicable |
Study Type : | Interventional (Clinical Trial) |
Actual Enrollment : | 10 participants |
Allocation: | Randomized |
Intervention Model: | Crossover Assignment |
Masking: | Single (Participant) |
Primary Purpose: | Basic Science |
Official Title: | Mechanism of Absorption and Distribution of Tocotrienols Under Different Food Status |
Study Start Date : | September 2009 |
Actual Primary Completion Date : | September 2009 |
Actual Study Completion Date : | September 2009 |
Arm | Intervention/treatment |
---|---|
Experimental: High fat
500 mg of tocotrienol will be administered at single dose after consumption of high fat diet
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Dietary Supplement: Tocotrienol
500 mg of tocotrienol will be administered after consumption of high fat diet |
Experimental: Low fat
500 mg of tocotrienol will be administered at single dose after consumption of low fat diet
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Dietary Supplement: Tocotrienol
500 mg of tocotrienol will be administered after consumption of low fat diet |
- Difference in absorption and distribution of Tocoterienols during high fat and low fat meal by measuring the plasma, chylomicron, and HDL level of tocotrienol [ Time Frame: 0, 0.5, 1, 1.5, 2, 3, 4, 5, 6, 24 hours after tocotrienol administration and in take of designated meal ]

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Ages Eligible for Study: | 22 Years to 25 Years (Adult) |
Sexes Eligible for Study: | Male |
Accepts Healthy Volunteers: | Yes |
Inclusion Criteria:
- male aged 22-25
- body mass index 18.5 < X < 30 kg/m2
- plasma cholesterol < 5.2 mmol/L,
- TAG < 1.7 mmol/L
Exclusion Criteria:
- history of cardiovascular disease
- diabetic
- body mass index < 18.5 or > 30 kg/m2
- plasma cholesterol > 5.2 mmol/L,
- TAG > 1.7 mmol/L
- hypertension
- currently taking Vitamin E supplement
- current use of medication
- smoking.

To learn more about this study, you or your doctor may contact the study research staff using the contact information provided by the sponsor.
Please refer to this study by its ClinicalTrials.gov identifier (NCT number): NCT01185769
Malaysia | |
Malaysian Palm Oil Board | |
Bangi, Selangor, Malaysia, 43000 |
Principal Investigator: | Weng-Yew Wong, Bsc | Malaysia Palm Oil Board |
Responsible Party: | Wong Weng-Yew / Research Officer, Malaysian Palm Oil Board |
ClinicalTrials.gov Identifier: | NCT01185769 |
Other Study ID Numbers: |
PD141/09 |
First Posted: | August 20, 2010 Key Record Dates |
Last Update Posted: | August 20, 2010 |
Last Verified: | August 2010 |
Vitamin E Absorption |
Tocotrienols Vitamin E Tocopherols Antioxidants Molecular Mechanisms of Pharmacological Action |
Protective Agents Physiological Effects of Drugs Vitamins Micronutrients |