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Prospective Study on the Incidence of Adrenal Crisis in Patients With Chronic Adrenal Insufficiency

This study has been completed.
Ludwig-Maximilians - University of Munich
Charite University, Berlin, Germany
Information provided by (Responsible Party):
Bruno Allolio, University of Wuerzburg Identifier:
First received: August 17, 2010
Last updated: January 3, 2014
Last verified: January 2014
Prospective study to evaluate incidence, causes and potential risk factors for adrenal crisis in patients with chronic adrenal insufficiency.

Adrenal Insufficiency

Study Type: Observational
Study Design: Observational Model: Cohort
Time Perspective: Prospective
Official Title: Prospective Cohort-study on the Incidence of Adrenal Crisis in Patients With Chronic Adrenal Insufficiency

Resource links provided by NLM:

Further study details as provided by University of Wuerzburg:

Primary Outcome Measures:
  • incidence of adrenal crisis [ Time Frame: during study period ]

Secondary Outcome Measures:
  • mortality [ Time Frame: during study period ]

Other Outcome Measures:
  • hospital admission [ Time Frame: during study period ]

Enrollment: 444
Study Start Date: February 2007
Study Completion Date: August 2011
Primary Completion Date: August 2011 (Final data collection date for primary outcome measure)
Detailed Description:
This is a prospective study following patients with chronic adrenal insufficiency by contacting them every 6 months via questionnaires and telephone. QUestionnaires assess incidence and causes of adrenal crisis, frequency of hospitalization.

Ages Eligible for Study:   18 Years and older   (Adult, Senior)
Sexes Eligible for Study:   All
Accepts Healthy Volunteers:   No
Sampling Method:   Probability Sample
Study Population
adult patients with chronic secondary or primary adrenal failure

Inclusion Criteria:

  • chronic primary or secondary adrenal insufficiency requiring glucocorticoid substitution therapy

Exclusion Criteria:

  • adrenocortical carcinoma
  • long term glucocorticoid treatment above 7.5 mg prednisone equivalent dose for other reasons than adrenal insufficiency
  • age < 18 years
  Contacts and Locations
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Please refer to this study by its identifier: NCT01184209

University of Berlin
Berlin, Germany, D-10117
University of Wuerzburg
Wuerzburg, Germany, D-97080
Sponsors and Collaborators
University of Wuerzburg
Ludwig-Maximilians - University of Munich
Charite University, Berlin, Germany
Study Chair: Bruno Allolio, MD University of Wuerzburg
  More Information

Publications automatically indexed to this study by Identifier (NCT Number):
Responsible Party: Bruno Allolio, MD, University of Wuerzburg Identifier: NCT01184209     History of Changes
Other Study ID Numbers: WueAC17/07
Study First Received: August 17, 2010
Last Updated: January 3, 2014

Additional relevant MeSH terms:
Adrenal Insufficiency
Adrenal Gland Diseases
Endocrine System Diseases
Epinephryl borate
Adrenergic alpha-Agonists
Adrenergic Agonists
Adrenergic Agents
Neurotransmitter Agents
Molecular Mechanisms of Pharmacological Action
Physiological Effects of Drugs
Adrenergic beta-Agonists
Bronchodilator Agents
Autonomic Agents
Peripheral Nervous System Agents
Anti-Asthmatic Agents
Respiratory System Agents
Vasoconstrictor Agents processed this record on May 25, 2017