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Mitochondrial Dysfunction and Oxidative Stress in Chronic Obstructive Pulmonary Disease (COPD) Patients

This study has been completed.
Sponsor:
ClinicalTrials.gov Identifier:
NCT01183052
First Posted: August 17, 2010
Last Update Posted: September 5, 2012
The safety and scientific validity of this study is the responsibility of the study sponsor and investigators. Listing a study does not mean it has been evaluated by the U.S. Federal Government. Read our disclaimer for details.
Collaborators:
Centre Hospitalier Régional Universitaire Montpellier
Institut National de la Santé Et de la Recherche Médicale, France
Information provided by (Responsible Party):
5 Santé
  Purpose
The purpose of this study is to understand the underlying mechanisms of improved exercise tolerance in COPD patients after training program.

Condition Intervention
COPD Patients Other: Training

Study Type: Interventional
Study Design: Intervention Model: Single Group Assignment
Masking: None (Open Label)
Official Title: Mitochondrial Respiratory Chain and Peripheral Muscle Dysfunction in COPD Patients

Further study details as provided by 5 Santé:

Primary Outcome Measures:
  • Cellular effects of exercise training at the ventilatory threshold intensity [ Time Frame: 6 to 8 weeks ]

Enrollment: 30
Study Start Date: June 2009
Study Completion Date: December 2010
Primary Completion Date: December 2010 (Final data collection date for primary outcome measure)
Arms Assigned Interventions
Training
20 sessions of training
Other: Training
20 sessions of training
Other Name: CT

Detailed Description:
Training protocol used is based on recommendations (Nici et al., 2006) and was previously used in our group (Varray et al., 1991; Vallet et al., 1997). A minimum of 20 sessions in 4-6 weeks were proposed. The exercise intensity of exercise corresponds to target heart rate at ventilatory threshold measured during incremental exercise test. Training at this intensity allowed us to individualize effort for each patient.
  Eligibility

Information from the National Library of Medicine

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Ages Eligible for Study:   50 Years to 75 Years   (Adult, Senior)
Sexes Eligible for Study:   All
Accepts Healthy Volunteers:   No
Criteria

Inclusion Criteria:

  • Sedentary mild to severe COPD patients

Exclusion Criteria:

  • Neuromuscular disease
  • Chronic heart failure
  • Renal diseases
  • Liver diseases
  • Obesity
  Contacts and Locations
Information from the National Library of Medicine

To learn more about this study, you or your doctor may contact the study research staff using the contact information provided by the sponsor.

Please refer to this study by its ClinicalTrials.gov identifier (NCT number): NCT01183052


Locations
France
Clinique du Souffle La Vallonie
Lodeve, France, 34700
Clinique du Souffle la Solane
Osseja, France, 66340
Sponsors and Collaborators
5 Santé
Centre Hospitalier Régional Universitaire Montpellier
Institut National de la Santé Et de la Recherche Médicale, France
Investigators
Principal Investigator: Maurice MH Hayot, MCU-PH Institut National de la Santé Et de la Recherche Médicale, France
  More Information

Responsible Party: 5 Santé
ClinicalTrials.gov Identifier: NCT01183052     History of Changes
Other Study ID Numbers: 2009-A00426-51
First Submitted: August 16, 2010
First Posted: August 17, 2010
Last Update Posted: September 5, 2012
Last Verified: September 2012

Keywords provided by 5 Santé:
COPD
exercise tolerance
oxidative stress

Additional relevant MeSH terms:
Pulmonary Disease, Chronic Obstructive
Lung Diseases, Obstructive
Lung Diseases
Respiratory Tract Diseases