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Effects of Training in Healthy Sedentary Subjects

This study has been completed.
Sponsor:
ClinicalTrials.gov Identifier:
NCT01183039
First Posted: August 17, 2010
Last Update Posted: September 5, 2012
The safety and scientific validity of this study is the responsibility of the study sponsor and investigators. Listing a study does not mean it has been evaluated by the U.S. Federal Government. Read our disclaimer for details.
Collaborators:
Centre Hospitalier Régional Universitaire Montpellier
Institut National de la Santé Et de la Recherche Médicale, France
Information provided by (Responsible Party):
5 Santé
  Purpose
The purpose of this study is to understand underlying mechanisms of improved exercise tolerance in Healthy Sedentary Subjects after training program.

Condition Intervention
Sedentary Subjects Other: Training

Study Type: Interventional
Study Design: Allocation: Randomized
Intervention Model: Parallel Assignment
Masking: None (Open Label)
Official Title: Cellular Effects of Training in Healthy Sedentary Subjects

Resource links provided by NLM:


Further study details as provided by 5 Santé:

Primary Outcome Measures:
  • Effects of training program on mitochondrial function and oxidative stress [ Time Frame: 6 to 8 weeks ]

Secondary Outcome Measures:
  • Relationship between mitochondrial function, oxidative stress and exercise tolerance in COPD patients [ Time Frame: 6 to 8 weeks ]

Enrollment: 30
Study Start Date: May 2008
Study Completion Date: December 2010
Primary Completion Date: December 2010 (Final data collection date for primary outcome measure)
Arms Assigned Interventions
Active Comparator: Ventilatory threshold
Training at the ventilatory threshold
Other: Training
20 sessions of training
Other Names:
  • Vt
  • Mt
Active Comparator: Metabolic threshold
Training at the metabolic threshold
Other: Training
20 sessions of training
Other Names:
  • Vt
  • Mt

Detailed Description:
Training protocol used is based on recommendations. A minimum of 20 sessions in 4-6 weeks were proposed. The exercise intensity of exercise corresponds to target heart rate at ventilatory threshold measured during incremental exercise test. Training at this intensity allowed us to individualize effort for each patient.
  Eligibility

Information from the National Library of Medicine

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Ages Eligible for Study:   50 Years to 75 Years   (Adult, Senior)
Sexes Eligible for Study:   All
Accepts Healthy Volunteers:   No
Criteria

Inclusion Criteria:

  • healthy Sedentary Subjects

Exclusion Criteria:

  • neuromuscular disease
  • chronic heart failure
  • diabetes
  • renal diseases
  • liver diseases
  Contacts and Locations
Information from the National Library of Medicine

To learn more about this study, you or your doctor may contact the study research staff using the contact information provided by the sponsor.

Please refer to this study by its ClinicalTrials.gov identifier (NCT number): NCT01183039


Locations
France
Clinique du souffle La valonie
Lodeve, France
hopital Arnaud de Vilneuve
Montpellier, France
Clinique du souffle La solane
Osseja, France
Sponsors and Collaborators
5 Santé
Centre Hospitalier Régional Universitaire Montpellier
Institut National de la Santé Et de la Recherche Médicale, France
Investigators
Principal Investigator: Maurice MH Hayot, MCU-PH Institut National de la Santé Et de la Recherche Médicale, France
  More Information

Responsible Party: 5 Santé
ClinicalTrials.gov Identifier: NCT01183039     History of Changes
Other Study ID Numbers: 2008-A00209-46
First Submitted: August 16, 2010
First Posted: August 17, 2010
Last Update Posted: September 5, 2012
Last Verified: September 2012

Keywords provided by 5 Santé:
Sedentary