Breath Analysis for Evaluation of Radiation Exposure in Lung Cancer Patients Treated With Radiation
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Patients treated with radiation therapy for lung tumors can experience inflammation after treatment. This study hopes to evaluate the use of breath analysis to evaluate changes in the composition of exhaled breath in patients undergoing radiotherapy. If changes can be detected, this may ultimately serve as biomarkers for identifying patients at highest risk for radiation-induced lung injury (radiation pneumonitis).
Condition or disease
Lung CancerNon-Small Cell Lung CancerSmall Cell Lung Cancer
Pre and post-radiation FeNO (fraction of exhaled nitric oxide) measurements [ Time Frame: Every 3 months for 1 year ]
Secondary Outcome Measures :
Pre and post-radiation CO (carbon monoxide), CO2 (carbon dioxide), and N2O (nitrous oxide) measurements and feasibility as the fraction of patients unable to give a breath sample. Adverse events are not expected but any that appear related to the breath [ Time Frame: 1 yr ]
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Ages Eligible for Study:
18 Years and older (Adult, Older Adult)
Sexes Eligible for Study:
Accepts Healthy Volunteers:
Patients with lung tumors who are undergoing radiation therapy
Diagnosis of any type of lung tumor
Medical recommendation (independent of the study) that the patient undergo thoracic radiation therapy. Radiation therapy may be either fractionated or hypofractionated (i.e. radiosurgery)
Age >= 18 years old
Any gender and any ethnic background will be recruited