The Importance of Periostin in Periodontal Health and Disease
|ClinicalTrials.gov Identifier: NCT01180920|
Recruitment Status : Completed
First Posted : August 12, 2010
Last Update Posted : December 2, 2014
|Condition or disease|
|Periodontal Disease Non-diseased Patients|
|Study Type :||Observational|
|Actual Enrollment :||22 participants|
|Observational Model:||Case Control|
|Official Title:||The Importance of Periostin in Periodontal Health and Disease|
|Study Start Date :||June 2011|
|Actual Primary Completion Date :||February 2013|
|Actual Study Completion Date :||February 2013|
11 patients with periodontal disease, specifically generalized chronic or aggressive periodontitis will be selected. In general, the disease group will be comprised of subjects that need an open flap procedure.
11 patients without periodontal disease will be selected. In general, the healthy group will be comprised of subjects that are requiring a gingivectomy or crown lengthening procedure.
- To determine whether the expression of Periostin within the periodontal tissues is affected in periodontal disease progression in-vivo and whether Periostin levels are associated with disease susceptibility. [ Time Frame: Baseline ]Periostin levels from gingival crevicular fluid (GCF), saliva, serum and tissue will be analyzed in both health and disease. Total RNA and protein extracts will be isolated and utilized for relative quantitative measurements.
- explore the expression dynamics of Periostin during periodontal healing in healthy and diseased periodontia. [ Time Frame: 8wks ]A longitudinal study will also be performed to evaluate Periostin levels in GCF/wound fluids and saliva over time during periodontal tissue healing and homeostasis.
Biospecimen Retention: Samples With DNA
Please refer to this study by its ClinicalTrials.gov identifier (NCT number): NCT01180920
|United States, Michigan|
|Michigan Center for Oral Health Research|
|Ann Arbor, Michigan, United States, 48106|
|Principal Investigator:||Hector Rios, MS, DDS||University of Michigan|
|Study Director:||William V Giannobile, DDS, DMSc||University of Michigan|