Tissue Doppler Imaging (TDI) Versus Electrocardiography (ECG) Interventricular Pacing Delay Optimization in Cardiac Resynchronization Therapy (CRT)
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|ClinicalTrials.gov Identifier: NCT01179997|
Recruitment Status : Completed
First Posted : August 11, 2010
Last Update Posted : February 27, 2014
|Condition or disease||Intervention/treatment||Phase|
|Heart Failure Cardiac Resynchronization Therapy||Device: Interventricular pacing delay optimization by using Tissue Doppler-derived displacement curves Device: Electrocardiographic optimization of the interventricular pacing delay according to QRS width||Phase 3|
|Study Type :||Interventional (Clinical Trial)|
|Actual Enrollment :||156 participants|
|Intervention Model:||Parallel Assignment|
|Masking:||Quadruple (Participant, Care Provider, Investigator, Outcomes Assessor)|
Active Comparator: Tissue Doppler Imaging (TDI) optimization
Interventricular pacing delay optimized according to Tissue-Doppler echocardiography
|Device: Interventricular pacing delay optimization by using Tissue Doppler-derived displacement curves|
Active Comparator: Electrocardiographic optimization
Interventricular pacing delay optimized according to QRS width observation in the 12-lead surface electrocardiogram
|Device: Electrocardiographic optimization of the interventricular pacing delay according to QRS width|
- 6-month echocardiographic responseReduction of the end-systolic volume (measured in mililiters according to transthoracic echocardiography) of >10% as compared to the baseline value.
- 6-month clinical responseCombined end-point consisting in no death due to cardiovascular reasons, no heart transplantation and distance increase of >10% (measured in meters) in the 6-minute walking test.
To learn more about this study, you or your doctor may contact the study research staff using the contact information provided by the sponsor.
Please refer to this study by its ClinicalTrials.gov identifier (NCT number): NCT01179997
|Hospital Clinic Universitari|
|Barcelona, Catalonia, Spain|