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Lifestyle Modifications and the Progression of Chronic Kidney Disease

This study has been completed.
Western New England Renal & Transplant Associates
Information provided by:
Springfield College Identifier:
First received: August 10, 2010
Last updated: NA
Last verified: January 2006
History: No changes posted

Aerobic training has been shown to favorably alter several of the known risk factors for coronary artery disease including hypertension, dyslipidemia, obesity, and diabetes (1). It seems logical that if these risk factors were aggressively controlled in patients with chronic kidney disease (CKD) by implementing lifestyle changes (e.g., diet and exercise training) to support the pharmacologic interventions that are necessary for the control of the disease, then the rate of progression of the disease may be altered. However, to date, there is no clear research evidence to support this hypothesis. Therefore the aims of the proposed study are:

  1. To test the hypothesis that lifestyle interventions (i.e., dietary modification and regular, long-term aerobic exercise training) will favorably alter the natural progression of CKD in a sample of patients compared to a control group who will receive the current standard care.
  2. To explore possible mechanisms that could contribute to the observed changes.

Condition Intervention
Patients With Stage 2-4 Chronic Kidney Disease Behavioral: Exercise training Behavioral: Diet modification

Study Type: Interventional
Study Design: Allocation: Randomized
Intervention Model: Parallel Assignment
Masking: Open Label
Primary Purpose: Prevention
Official Title: Effect of Lifestyle Interventions on the Progression of Kidney Disease in Patients With Chronic Kidney Disease

Resource links provided by NLM:

Further study details as provided by Springfield College:

Primary Outcome Measures:
  • Glomerular filtration rate (GFR) [ Time Frame: 48 weeks ]
    GFR was estimated using the MDRD equation, creatinine clearance, urea clearance

Secondary Outcome Measures:
  • 24 hour urine protein output [ Time Frame: 48 weeks ]
    urine protein output is measured before and after 48 weeks of the training program

Enrollment: 21
Study Start Date: January 2006
Study Completion Date: February 2009
Primary Completion Date: February 2009 (Final data collection date for primary outcome measure)
Arms Assigned Interventions
Experimental: Lifestyle intervention-exercise & diet
Subjects trained for 48 weeks with a personal trainer
Behavioral: Exercise training
Subjects exercise trained for 48 weeks with personal trainers at a college wellness center
Behavioral: Diet modification
Exercise training using personal trainers 3 times per week. Individuals were trained at a moderate intensity


Ages Eligible for Study:   20 Years to 70 Years   (Adult, Senior)
Sexes Eligible for Study:   All
Accepts Healthy Volunteers:   No

Inclusion Criteria:

  • Stages 2-4 CKD

Exclusion Criteria:

  • CAD
  • MI
  Contacts and Locations
Choosing to participate in a study is an important personal decision. Talk with your doctor and family members or friends about deciding to join a study. To learn more about this study, you or your doctor may contact the study research staff using the Contacts provided below. For general information, see Learn About Clinical Studies.

Please refer to this study by its identifier: NCT01179906

United States, Massachusetts
Springfield College
Springfield, Massachusetts, United States, 01109
Sponsors and Collaborators
Springfield College
Western New England Renal & Transplant Associates
Principal Investigator: Sam A Headley, Ph.D Springfield College
  More Information

Responsible Party: Samuel Headley, Springfield College Identifier: NCT01179906     History of Changes
Other Study ID Numbers: BHS research incubator study
Study First Received: August 10, 2010
Last Updated: August 10, 2010

Keywords provided by Springfield College:

Additional relevant MeSH terms:
Kidney Diseases
Renal Insufficiency, Chronic
Urologic Diseases
Renal Insufficiency processed this record on July 25, 2017