Prevalence of Microcirculatory Alterations in Intensive Care Patients
Recent research has focused on the investigation of sublingual microcirculatory alterations in different patient categories, like cardiac surgery and sepsis. The microcirculation plays a pivotal role in tissue oxygenation and can be non invasively visualized by sidestream dark field (SDF) imaging.
The objective is to carry out a international multi center study to investigate the prevalence of microcirculatory alterations in intensive care patients. Up to the present time, a comprehensive prevalence study like this has not been carried out.
|Study Design:||Observational Model: Case-Only
Time Perspective: Cross-Sectional
|Official Title:||Observation of the Prevalence of Sublingual Microcirculatory Alterations With SDF Imaging in Intensive Care Patients|
- microcirculatory alterations related to underlying illness, expressed as - amongst others- microvascular flow index (MFI), proportion of perfused vessels (PPV). [ Time Frame: 24 hours ] [ Designated as safety issue: No ]
- microcirculatory alterations related to: hospital/intensive care length of stay mortality severity of illness [ Time Frame: 28 days ] [ Designated as safety issue: No ]
|Study Start Date:||September 2011|
|Study Completion Date:||May 2012|
|Primary Completion Date:||December 2011 (Final data collection date for primary outcome measure)|
intensive care patients
Visualization of the sublingual microcirculation at a fixed time point with SDF- or OPS-imaging in all adult patients of participating intensive care units, regardless of their underlying disease. Concurrently, data on both patient characteristics (e.g. severity of illness, treatment) and ICU characteristics will be obtained.
Please refer to this study by its ClinicalTrials.gov identifier: NCT01179243
|Gelre Ziekenhuis Apeldoorn|
|Medical Centre Leeuwarden|
|Leeuwarden, Netherlands, 8934 AD|
|Erasmus MC Rotterdam|
|Principal Investigator:||E.C. Boerma, MD, PhD||Medical Centre Leeuwarden, the Netherlands|