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Rubidium-82 Position Emission Computed Tomography (PET) Versus Gated, Rest / Stress Technetium 99-m SPECT (PETvsSPECT)

This study has been completed.
ClinicalTrials.gov Identifier:
First Posted: August 11, 2010
Last Update Posted: March 23, 2015
The safety and scientific validity of this study is the responsibility of the study sponsor and investigators. Listing a study does not mean it has been evaluated by the U.S. Federal Government. Read our disclaimer for details.
Bracco Diagnostics, Inc
Information provided by (Responsible Party):
Hartford Hospital
Many stress tests being done today have two parts, the stress test and the pictures of your heart. The investigators are comparing a newer technique to obtain the pictures (PET imaging) to the standard method (SPECT imaging). However, it is not known if the new test is better than the old test. It is important to have a standard to compare these tests to, and that is why people who will be getting a cardiac catheterization are being asked to participate. The information about your arteries from the cardiac catheterization will be used to judge which stress test is better. The investigators hypothesize that the newer method (PET imaging) will be more accurate than the old method (SPECT) in detecting heart disease.

Condition Intervention
Coronary Artery Disease Myocardial Ischemia Heart Disease Other: SPECT imaging Other: PET imaging

Study Type: Observational
Study Design: Observational Model: Cohort
Time Perspective: Prospective
Official Title: A Prospective Comparison of Gated, Rest/Stress Rubidium-82 Position Emission Computed Tomography (PET) vs. Gated, Rest / Stress Technetium 99-m SPECT

Resource links provided by NLM:

Further study details as provided by Hartford Hospital:

Primary Outcome Measures:
  • Coronary Artery Disease [ Time Frame: 30 days ]

Secondary Outcome Measures:
  • Myocardial Ischemia [ Time Frame: 30 days ]

Enrollment: 136
Study Start Date: January 2005
Study Completion Date: December 2012
Primary Completion Date: December 2012 (Final data collection date for primary outcome measure)
Groups/Cohorts Assigned Interventions
Subjects will have both types of imaging performed, PET and SPECT
Other: SPECT imaging
Dipyridamole stress testing 0.57 mg/kg
Other Names:
  • Pharmacological stress testing
  • Myocardial perfusion imaging
  • Persantine stress test
Other: PET imaging
Dipyridamole stress test 0.57 mg/kg with Rubidium PET images
Other Names:
  • PET perfusion images
  • Rb-92
  • PET persantine stress test

Detailed Description:
A SPECT rest image will be obtained using a technetium based isotope. On a separate day, a Rubidium rest PET image will be obtained prior to a Dipyridamole stress test. Subjects will receive both Rubidium and technetium isotopes following the Dipyridamole stress, and will undergo first PET imaging and later SPECT imaging following the stress test. Patients will then go for cardiac catheterization as clinically ordered by their physician.

Information from the National Library of Medicine

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Ages Eligible for Study:   50 Years and older   (Adult, Senior)
Sexes Eligible for Study:   All
Accepts Healthy Volunteers:   No
Sampling Method:   Non-Probability Sample
Study Population
Patients with intermediate to high likelihood of CAD referred for cardiac catheterization, either on outpatient or inpatient basis

Inclusion Criteria:

  • referred for clinical cardiac catheterization

Exclusion Criteria:

  • previous CABG
  • previous MI
  • Asthma or obstructive airway disease
  • Intolerance to Dipyridamole
  • Moderate to severe valvular disease
  • Cardiomyopathy - (ejection fraction less than 45%)
  Contacts and Locations
Information from the National Library of Medicine

To learn more about this study, you or your doctor may contact the study research staff using the contact information provided by the sponsor.

Please refer to this study by its ClinicalTrials.gov identifier (NCT number): NCT01179230

United States, Alabama
The Heart Center, PC
Huntsville, Alabama, United States, 35801
United States, Connecticut
Hartford Hospital
Hartford, Connecticut, United States, 06102-5037
United States, Missouri
Cardiovascular Imaging Technologies, LLC
Kansas City, Missouri, United States, 64111
United States, North Dakota
Sanford Health Clinical Research
Fargo, North Dakota, United States, 58122-0011
United States, Ohio
Ohio Health Research Institute
Columbus, Ohio, United States, 43214
Sponsors and Collaborators
Hartford Hospital
Bracco Diagnostics, Inc
Principal Investigator: Gary V. Heller, M.D., Ph.D. Hartford Hospital
  More Information

Responsible Party: Hartford Hospital
ClinicalTrials.gov Identifier: NCT01179230     History of Changes
Other Study ID Numbers: HELL001671HE
First Submitted: June 8, 2010
First Posted: August 11, 2010
Last Update Posted: March 23, 2015
Last Verified: July 2012

Keywords provided by Hartford Hospital:
chest pain
acute coronary syndrome
Myocardial perfusion imaging

Additional relevant MeSH terms:
Coronary Artery Disease
Myocardial Ischemia
Coronary Disease
Heart Diseases
Cardiovascular Diseases
Arterial Occlusive Diseases
Vascular Diseases
Pathologic Processes
Phosphodiesterase Inhibitors
Enzyme Inhibitors
Molecular Mechanisms of Pharmacological Action
Platelet Aggregation Inhibitors
Vasodilator Agents