A Dangerous Triad in Ageing and in Chronic Obstructive Pulmonary Disease (COPD) - Reduced Muscle Mass, Impaired Muscle Function and Malnutrition
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|ClinicalTrials.gov Identifier: NCT01179178|
Recruitment Status : Completed
First Posted : August 11, 2010
Last Update Posted : August 11, 2010
The investigators have taken part in the development of simple muscle function tests and studied physical training and energy turnover in patients with chronic obstructive pulmonary disease, COPD. The investigators have found that muscle wasting in COPD is related to poor prognosis and that physical training might lead to improved, less energy-demanding muscle function. Elderly subjects also suffer from muscle wasting that leads to frailty, poor autonomy and, secondarily, fractures. In the planned study the investigators will validate simple muscle function tests (hand grip strength, heel rise test, voluntary quadriceps muscle strength, 30 m walking test and balance tests) in both groups by relating them to an involuntary, magnet stimulated, test of quadriceps force, HRQL, tests of body composition (impedance, DXA) and recordings of physical activity. The relation between food intake, systemic inflammation, muscle mass and function will be analysed.
The study has been ethically approved and started in COPD patients and will be expanded to a representative sample of elderly.
Simple, evaluated muscle function tests applied in primary care may be used for early detection of muscle dysfunction in COPD patients and elderly so that early intervention against impaired muscle function can be started. Analyses of food intake and of inflammatory markers might identify factors of special importance for muscle dysfunction, which eventually might lead to improved dietary therapy and pharmacological interventions.
|Condition or disease|
|Pulmonary Disease, Chronic Obstructive|
|Study Type :||Observational|
|Observational Model:||Case Control|
|Official Title:||A Dangerous Triad in Ageing and in COPD - Reduced Muscle Mass, Impaired Muscle Function and Malnutrition|
|Study Start Date :||March 2006|
|Actual Primary Completion Date :||December 2009|
|Actual Study Completion Date :||December 2009|
|Older adults (65-81 y)|
To learn more about this study, you or your doctor may contact the study research staff using the contact information provided by the sponsor.
Please refer to this study by its ClinicalTrials.gov identifier (NCT number): NCT01179178
|Dept of Clinical Nutrition, Sahlgrenska Academy at University of Gothenburg|
|Göteborg, Sweden, 44232|