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A Dangerous Triad in Ageing and in Chronic Obstructive Pulmonary Disease (COPD) - Reduced Muscle Mass, Impaired Muscle Function and Malnutrition

This study has been completed.
The Swedish Research Council
The Swedish Heart and Lung Association
Swedish Heart Lung Foundation
Information provided by:
Göteborg University Identifier:
First received: August 9, 2010
Last updated: August 10, 2010
Last verified: January 2006

The investigators have taken part in the development of simple muscle function tests and studied physical training and energy turnover in patients with chronic obstructive pulmonary disease, COPD. The investigators have found that muscle wasting in COPD is related to poor prognosis and that physical training might lead to improved, less energy-demanding muscle function. Elderly subjects also suffer from muscle wasting that leads to frailty, poor autonomy and, secondarily, fractures. In the planned study the investigators will validate simple muscle function tests (hand grip strength, heel rise test, voluntary quadriceps muscle strength, 30 m walking test and balance tests) in both groups by relating them to an involuntary, magnet stimulated, test of quadriceps force, HRQL, tests of body composition (impedance, DXA) and recordings of physical activity. The relation between food intake, systemic inflammation, muscle mass and function will be analysed.

The study has been ethically approved and started in COPD patients and will be expanded to a representative sample of elderly.

Simple, evaluated muscle function tests applied in primary care may be used for early detection of muscle dysfunction in COPD patients and elderly so that early intervention against impaired muscle function can be started. Analyses of food intake and of inflammatory markers might identify factors of special importance for muscle dysfunction, which eventually might lead to improved dietary therapy and pharmacological interventions.

Pulmonary Disease, Chronic Obstructive

Study Type: Observational
Study Design: Observational Model: Case Control
Time Perspective: Prospective
Official Title: A Dangerous Triad in Ageing and in COPD - Reduced Muscle Mass, Impaired Muscle Function and Malnutrition

Resource links provided by NLM:

Further study details as provided by Göteborg University:

Study Start Date: March 2006
Study Completion Date: December 2009
Primary Completion Date: December 2009 (Final data collection date for primary outcome measure)
Older adults (65-81 y)


Ages Eligible for Study:   65 Years to 81 Years   (Adult, Senior)
Sexes Eligible for Study:   All
Accepts Healthy Volunteers:   Yes
Sampling Method:   Probability Sample
Study Population
Outpatients (COPD) and older adults living in Gothenburg

Inclusion Criteria:

  • Women and men between 65 and 81 years of age, randomly selected from the national registration, are invited to take part in the study.
  • Patients referred to the outpatient clinic of the lung unit at Sahlgrenska University Hospital with a diagnosis of COPD are asked for participation.
  • Inclusion criteria for COPD patients:
  • Clinical diagnosis of COPD
  • FEV% < normal value minus 2 SD
  • Smoking history; 10 pack years or more

Exclusion Criteria:

  • Any specific muscular disease
  • Severe disease or handicap making investigations impossible
  • Exclusion criteria for COPD patients:
  • Any specific muscular disease
  • Any co-existing serious disease
  Contacts and Locations
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Please refer to this study by its identifier: NCT01179178

Dept of Clinical Nutrition, Sahlgrenska Academy at University of Gothenburg
Göteborg, Sweden, 44232
Sponsors and Collaborators
Göteborg University
The Swedish Research Council
The Swedish Heart and Lung Association
Swedish Heart Lung Foundation
  More Information Identifier: NCT01179178     History of Changes
Other Study ID Numbers: UGOTTriad
Grant ( Other Grant/Funding Number: The Swedish Research Council 2006-3320 )
Study First Received: August 9, 2010
Last Updated: August 10, 2010

Additional relevant MeSH terms:
Lung Diseases
Pulmonary Disease, Chronic Obstructive
Chronic Disease
Respiratory Tract Diseases
Lung Diseases, Obstructive
Nutrition Disorders
Disease Attributes
Pathologic Processes processed this record on September 21, 2017