Sonographic Differences in Brain Measurements Between Normal and Intrauterine Growth Restriction (IUGR) Fetuses

The safety and scientific validity of this study is the responsibility of the study sponsor and investigators. Listing a study does not mean it has been evaluated by the U.S. Federal Government. Read our disclaimer for details. Identifier: NCT01178619
Recruitment Status : Withdrawn
First Posted : August 10, 2010
Last Update Posted : August 28, 2013
Information provided by (Responsible Party):
Meir Medical Center

Brief Summary:
Intrauterine growth restriction is being suspected in cases where the fetal estimated weight is less then the 10 th percentile for its gestational age. Abdominal circumference is the most influenced measurement in this cases. Head circumference on the other hand can be or not be influenced. Previous studies have shown that transverse cerebellar diameter (TCD) is constant to gestational age and is not influenced by IUGR.Other showed lower TCD in IUGR fetuses. We would like to study the differences in cerebellar, vermian and corpus callosum growth between normal to IUGR fetuses and between symmetrical and asymmetrical IUGR. In this observational study we will include pregnant women between 28-37 gestational week with a singleton otherwise normal pregnancies. We will measure the fetal TCD, vermian distances and the CC, abdominal circumference, head circumference and femur length. we will compeer these measurements according to the following groups:normal fetuses, symmetrical and asymmetrical IUGR.

Condition or disease
Intra-uterine Growth Restriction

Study Type : Observational
Actual Enrollment : 0 participants
Observational Model: Case Control
Study Start Date : September 2010
Estimated Primary Completion Date : August 2012
Actual Study Completion Date : August 2012

symmetrical IUGR
asymmetrical IUGR

Information from the National Library of Medicine

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Ages Eligible for Study:   28 Weeks to 37 Weeks   (Child)
Sexes Eligible for Study:   All
Accepts Healthy Volunteers:   Yes
Sampling Method:   Probability Sample
Study Population
pregnant women 28-37 GA, singleton, otherwise normal fetuses

Inclusion Criteria:

  • singleton,
  • 28-37 GA,
  • well dated pregnancy.

Exclusion Criteria:

  • multifetal pregnancies,
  • no first trimester dating,
  • fetuses with known chromosomal or structural anomalies.

Responsible Party: Meir Medical Center Identifier: NCT01178619     History of Changes
Other Study ID Numbers: MMC10095-2010CTIL
First Posted: August 10, 2010    Key Record Dates
Last Update Posted: August 28, 2013
Last Verified: August 2013

Keywords provided by Meir Medical Center:
IUGR fetuses
symmetrical IUGR
asymmetrical IUGR

Additional relevant MeSH terms:
Fetal Growth Retardation
Fetal Diseases
Pregnancy Complications
Growth Disorders
Pathologic Processes