Radiologic Features of Invasive Pulmonary Aspergillosis

The safety and scientific validity of this study is the responsibility of the study sponsor and investigators. Listing a study does not mean it has been evaluated by the U.S. Federal Government. Read our disclaimer for details. Identifier: NCT01178177
Recruitment Status : Completed
First Posted : August 10, 2010
Last Update Posted : May 16, 2013
Information provided by (Responsible Party):
Sung-Han Kim, Asan Medical Center

Brief Summary:
Invasive pulmonary aspergillosis (IPA) is an opportunistic infection that primarily affects recipients of solid organ transplants (SOTs) and patients with chemotherapy- induced neutropenia.Although both of these populations are at high risk for IPA, they differ with regards to the specific defects in host defense mechanisms that increase their risk for IPA. Chemotherapy- induced neutropenia is the principal defect affecting patients with hematologic malignancies, whereas transplant recipients tend to have dysfunctional T cells and phagocytes, as a result of immunosuppressive drug therapy. Thus, the patterns of IPA-related infection and inflammation may differ according to the type of underlying immune defect. Although the clinical and radiological features of IPA in patients with neutropenia have been extensively studied, little is known about the characteristics of IPA in SOT recipients. The investigators therefore compared the IPA- related clinical and radiological findings in SOT recipients with those of neutropenic patients.

Condition or disease
Hematologic Disease Solid Organ Transplantation

Study Type : Observational
Actual Enrollment : 130 participants
Observational Model: Cohort
Time Perspective: Retrospective
Official Title: Retrospective Analysis of Radiologic Features of Invasive Pulmonary Aspergillosis in Transplant Recipients and Neutropenic Patients.Transplant Recipients and Neutropenic Patients
Study Start Date : January 2008
Actual Primary Completion Date : February 2010
Actual Study Completion Date : February 2010

Resource links provided by the National Library of Medicine

U.S. FDA Resources

SOT recipients
solid organ transplant recipients with invasive pulmonary aspergillosis
Hematologic disease
Hematologic disease patients with invasive pulmonary aspergillosis

Information from the National Library of Medicine

Choosing to participate in a study is an important personal decision. Talk with your doctor and family members or friends about deciding to join a study. To learn more about this study, you or your doctor may contact the study research staff using the contacts provided below. For general information, Learn About Clinical Studies.

Ages Eligible for Study:   16 Years and older   (Child, Adult, Senior)
Sexes Eligible for Study:   All
Accepts Healthy Volunteers:   No
Sampling Method:   Probability Sample
Study Population
All adult patients who are diagnosed with invasive pulmonary aspergillosis (IPA)between January 2008 and February 2010.

Inclusion Criteria:

  • IPA cases with solid organ transplant recipients and hematologic disease patients
  • proven and probable invasive pulmonary aspergillosis by modified EORTC/MSG criteria

Exclusion Criteria:

  • under 16 years old
  • possible cases of invasive pulmonary aspergillosis

Information from the National Library of Medicine

To learn more about this study, you or your doctor may contact the study research staff using the contact information provided by the sponsor.

Please refer to this study by its identifier (NCT number): NCT01178177

Sponsors and Collaborators
Asan Medical Center
Study Chair: Sung-Han Kim, MD Department of Infectious Diseases, Asan Medical Center

Publications of Results:
Responsible Party: Sung-Han Kim, Assistantant Professor, Asan Medical Center Identifier: NCT01178177     History of Changes
Other Study ID Numbers: IPA -HEM vs SOT-2010
First Posted: August 10, 2010    Key Record Dates
Last Update Posted: May 16, 2013
Last Verified: May 2013

Keywords provided by Sung-Han Kim, Asan Medical Center:
Invasive pulmonary aspergillosis
Solid organ transplantation
Hematologic disease

Additional relevant MeSH terms:
Hematologic Diseases
Pulmonary Aspergillosis
Invasive Pulmonary Aspergillosis
Lung Diseases, Fungal
Skin Diseases, Infectious
Skin Diseases
Lung Diseases
Respiratory Tract Diseases
Invasive Fungal Infections