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Radiologic Features of Invasive Pulmonary Aspergillosis

This study has been completed.
Information provided by (Responsible Party):
Sung-Han Kim, Asan Medical Center Identifier:
First received: August 9, 2010
Last updated: May 14, 2013
Last verified: May 2013
Invasive pulmonary aspergillosis (IPA) is an opportunistic infection that primarily affects recipients of solid organ transplants (SOTs) and patients with chemotherapy- induced neutropenia.Although both of these populations are at high risk for IPA, they differ with regards to the specific defects in host defense mechanisms that increase their risk for IPA. Chemotherapy- induced neutropenia is the principal defect affecting patients with hematologic malignancies, whereas transplant recipients tend to have dysfunctional T cells and phagocytes, as a result of immunosuppressive drug therapy. Thus, the patterns of IPA-related infection and inflammation may differ according to the type of underlying immune defect. Although the clinical and radiological features of IPA in patients with neutropenia have been extensively studied, little is known about the characteristics of IPA in SOT recipients. The investigators therefore compared the IPA- related clinical and radiological findings in SOT recipients with those of neutropenic patients.

Hematologic Disease Solid Organ Transplantation

Study Type: Observational
Study Design: Observational Model: Cohort
Time Perspective: Retrospective
Official Title: Retrospective Analysis of Radiologic Features of Invasive Pulmonary Aspergillosis in Transplant Recipients and Neutropenic Patients.Transplant Recipients and Neutropenic Patients

Resource links provided by NLM:

Further study details as provided by Sung-Han Kim, Asan Medical Center:

Enrollment: 130
Study Start Date: January 2008
Study Completion Date: February 2010
Primary Completion Date: February 2010 (Final data collection date for primary outcome measure)
SOT recipients
solid organ transplant recipients with invasive pulmonary aspergillosis
Hematologic disease
Hematologic disease patients with invasive pulmonary aspergillosis


Ages Eligible for Study:   16 Years and older   (Child, Adult, Senior)
Sexes Eligible for Study:   All
Accepts Healthy Volunteers:   No
Sampling Method:   Probability Sample
Study Population
All adult patients who are diagnosed with invasive pulmonary aspergillosis (IPA)between January 2008 and February 2010.

Inclusion Criteria:

  • IPA cases with solid organ transplant recipients and hematologic disease patients
  • proven and probable invasive pulmonary aspergillosis by modified EORTC/MSG criteria

Exclusion Criteria:

  • under 16 years old
  • possible cases of invasive pulmonary aspergillosis
  Contacts and Locations
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Please refer to this study by its identifier: NCT01178177

Sponsors and Collaborators
Asan Medical Center
Study Chair: Sung-Han Kim, MD Department of Infectious Diseases, Asan Medical Center
  More Information

Responsible Party: Sung-Han Kim, Assistantant Professor, Asan Medical Center Identifier: NCT01178177     History of Changes
Other Study ID Numbers: IPA -HEM vs SOT-2010
Study First Received: August 9, 2010
Last Updated: May 14, 2013

Keywords provided by Sung-Han Kim, Asan Medical Center:
Invasive pulmonary aspergillosis
Solid organ transplantation
Hematologic disease

Additional relevant MeSH terms:
Hematologic Diseases
Pulmonary Aspergillosis
Invasive Pulmonary Aspergillosis
Skin Diseases, Infectious
Skin Diseases
Lung Diseases, Fungal
Lung Diseases
Respiratory Tract Diseases processed this record on September 21, 2017