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Prevalence of Potential Cytochrome P450 Pharmacokinetic Incident Drug-Drug Interactions(DDI) Among Osteoarthritis Patients

This study has been completed.
Information provided by (Responsible Party):
Joseph Pergolizzi, MD, NEMA Research, Inc. Identifier:
First received: August 5, 2010
Last updated: April 28, 2012
Last verified: April 2012
Using a retrospective database analysis, OA patients taking at least one CYP450-metabolized opioid (codeine, fentanyl, hydrocodone, methadone, oxycodone, or tramadol) and at least one other prescription drug metabolized via the CYP450 system were evaluated for an incident drug-drug exposure (DDE), which places them at risk for experiencing a pharmacokinetic drug-drug interaction (DDI).


Study Type: Observational
Study Design: Observational Model: Case Control
Time Perspective: Retrospective
Official Title: Prevalence of Potential Cytochrome P450 Pharmacokinetic Incident Drug-Drug Interactions Among Osteoarthritis Patients Taking Opioid Analgesics and Associated Economic Outcomes

Resource links provided by NLM:

Further study details as provided by Joseph Pergolizzi, MD, NEMA Research, Inc.:

Estimated Enrollment: 10000
Study Start Date: September 2010
Study Completion Date: January 2011
Primary Completion Date: December 2010 (Final data collection date for primary outcome measure)

Ages Eligible for Study:   18 Years to 65 Years   (Adult)
Sexes Eligible for Study:   All
Accepts Healthy Volunteers:   No
Sampling Method:   Non-Probability Sample
Study Population
retrospective database analysis

Inclusion Criteria:

  • osteoarthritis

Exclusion Criteria:

  • pregnancy
  Contacts and Locations
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Please refer to this study by its identifier: NCT01177267

Sponsors and Collaborators
NEMA Research, Inc.
Principal Investigator: Joseph Pergolizzi, MD NEMA Research
  More Information

Responsible Party: Joseph Pergolizzi, MD, Principal Investigator, NEMA Research, Inc. Identifier: NCT01177267     History of Changes
Other Study ID Numbers: CYP450OA3
Study First Received: August 5, 2010
Last Updated: April 28, 2012

Keywords provided by Joseph Pergolizzi, MD, NEMA Research, Inc.:
retrospective database analysis in osteoarthritis patients

Additional relevant MeSH terms:
Joint Diseases
Musculoskeletal Diseases
Rheumatic Diseases processed this record on May 25, 2017