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Adiponectin and Inflammatory Mediators in Mediastinal Adipose Tissues

The safety and scientific validity of this study is the responsibility of the study sponsor and investigators. Listing a study does not mean it has been evaluated by the U.S. Federal Government. Read our disclaimer for details. Identifier: NCT01176357
Recruitment Status : Unknown
Verified August 2010 by Far Eastern Memorial Hospital.
Recruitment status was:  Recruiting
First Posted : August 6, 2010
Last Update Posted : August 6, 2010
Information provided by:
Far Eastern Memorial Hospital

Brief Summary:
Coronary artery disease (CAD), the most common type of heart disease, is caused by hardening of the arteries, or atherosclerosis that is an inflammatory process in which immune mechanisms interact with metabolic risk factors to initiate, propagate, and activate lesions in the arterial trees. Epidemiological studies have found that increased cardiovascular risks are associated with increased levels of inflammatory cytokines (eg, interleukin-6 [IL-6] and tumor necrosis factor-alpha[TNF-alpha]) or their hepatic product, C-reactive protein (CRP). Higher expression of interleukin-Ibeta(IL-1beta),IL-6, monocyte chemotactic protein-1 (MCP-1), and TNF-alpha were observed in epicardial adipose tissues in patients with CAD. These findings suggested that the pericoronary tissues could be a source of inflammatory mediators or act as paracrine that lead to vascular inflammation on CAD pathogenesis. However, adiponectin, a kind of adipocytokine, produced and secreted exclusively by adipose tissue, has been reported to have a variety of anti-inflammatory functions against atherosclerosis, resulting in risk reduction for incidence of CAD events. It remains unclear whether adiponectin and inflammatory mediators in mediastinal adipose tissue contribute to CAD. We therefore aim to analyze the expression of adiponectin and inflammatory mediators in mediastinal adipose tissue between patients with CAD and with valve diseases, and to correlate these parameters with clinical atherosclerotic risks, medications (statins or antiplatelet), and blood sugar.

Condition or disease
Coronary Artery Disease Atherosclerosis

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Study Type : Observational
Estimated Enrollment : 60 participants
Observational Model: Case Control
Time Perspective: Cross-Sectional
Official Title: Adiponectin and Inflammatory Mediators in Mediastinal Adipose Tissues Between Patients With Coronary Artery Diseases and With Valvular Diseases
Study Start Date : January 2008
Estimated Primary Completion Date : December 2008

Resource links provided by the National Library of Medicine

Valve surgery

Biospecimen Retention:   Samples Without DNA
Adipose tissue biopsy samples from mediastinal fat, epicardial fat, subcutaneous fat in thoracic region or abdominal region and subcutaneous fat in leg were obtained soon after sternotomy or thoracotomy before the initiation of cardiopulmonary bypass.

Information from the National Library of Medicine

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Ages Eligible for Study:   18 Years and older   (Adult, Older Adult)
Sexes Eligible for Study:   All
Accepts Healthy Volunteers:   No
Sampling Method:   Probability Sample
Study Population
Patients with CAD or with valve diseases proposed to have cardiac operations

Inclusion Criteria:

  • patient underwent CABG or valve surgery in our hospital will be included

Exclusion Criteria:

  • liver disease
  • dhronic renal insufficiency
  • neoplastic diseases
  • taking steroids
  • congestive heart failure

Information from the National Library of Medicine

To learn more about this study, you or your doctor may contact the study research staff using the contact information provided by the sponsor.

Please refer to this study by its identifier (NCT number): NCT01176357

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Contact: Kuan-Ming Chiu, MD, PhD 886-2-89667000

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FEMH Recruiting
Taipei, Taiwan
Contact: Kuan-Ming Chiu, MD, PhD    886-2-89667000      
Sponsors and Collaborators
Far Eastern Memorial Hospital
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Principal Investigator: Kuan-Ming Chiu, MD, PhD FEMH

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Responsible Party: Shih-Hong Huang, Far Eastern Memorial Hospital Identifier: NCT01176357    
Other Study ID Numbers: 96039
First Posted: August 6, 2010    Key Record Dates
Last Update Posted: August 6, 2010
Last Verified: August 2010
Keywords provided by Far Eastern Memorial Hospital:
Coronary artery disease (CAD)
mediastinal adipose tissue
adiponectin, inflammatory mediators
Additional relevant MeSH terms:
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Coronary Artery Disease
Myocardial Ischemia
Coronary Disease
Heart Diseases
Cardiovascular Diseases
Arterial Occlusive Diseases
Vascular Diseases