Veteran Health Study

This study has been completed.
Information provided by (Responsible Party):
Department of Veterans Affairs Identifier:
First received: August 3, 2010
Last updated: June 30, 2014
Last verified: June 2014

The purpose of The Veteran Health Study (CSP #569) is to better understand the mental and physical health of veterans as they get older. We are inviting approximately 10,000 members of the Vietnam Era Twin (VET) Registry to participate. As veterans approach their mid-sixties, it is important to understand the impact of wartime deployment on health and mental health outcomes nearly 40 years later.

The investigators will assess the prevalence of post-traumatic stress disorder (PTSD) and other mental and physical health conditions for Vietnam era veterans, and explore the relationship between PTSD and other conditions.

CSP #569 involves 3 phases of data collection. In Phase I, VET Registry members are invited to complete a paper and pencil questionnaire including items on physical and mental health, disability, health behaviors, demographic information and use of health care services. After completing Phase I, VET Registry members are invited to Phase II which involves a telephone interview about mental health. In Phase III, some of those who participated in Phase I will be invited to a sub-study confirming self-reported heart disease and diabetes using a provider survey.

Data collected for CSP #569 will be combined with existing VET Registry data. This will provide a rich picture of the health of Vietnam era veterans and the influence of PTSD on the lives of veterans.

Stress Disorders, Post-Traumatic
Cardiovascular Disease

Study Type: Observational
Study Design: Observational Model: Cohort
Time Perspective: Cross-Sectional
Official Title: CSP #569 - A Twin Study of the Course and Consequences of PTSD in Vietnam Era Veterans

Resource links provided by NLM:

Further study details as provided by Department of Veterans Affairs:

Primary Outcome Measures:
  • Determine the prevalence of lifetime and current psychiatric conditions including PTSD in Vietnam Era Twin Registry members who served during the Vietnam Era. [ Time Frame: two years ] [ Designated as safety issue: No ]

Secondary Outcome Measures:
  • Characterize the physical health of Vietnam Era Twin Registry members who served during the Vietnam Era. [ Time Frame: two years ] [ Designated as safety issue: No ]
  • Characterize the level of current disability in Vietnam Era Twin Registry members who served during the Vietnam Era. [ Time Frame: two years ] [ Designated as safety issue: No ]

Enrollment: 7568
Study Start Date: January 2010
Study Completion Date: March 2013
Primary Completion Date: September 2012 (Final data collection date for primary outcome measure)
Group 1
The Vietnam Era Twin (VET) Registry is a closed cohort composed of 7,369 middle-aged male-male twin pairs both of whom served in the military during the time of the Vietnam conflict (1965-1975). The Registry is a United States Department of Veterans Affairs resource that was originally constructed from military records; the Registry has been in existence for more than 15 years. It is one of the largest national twin registries in the US and currently has subjects living in all 50 states. Initially formed to address questions about the long-term health effects of service in Vietnam the Registry has evolved into a resource for genetic epidemiological studies of mental and physical health conditions. Several waves of mail and telephone surveys have collected a wealth of health-related information on Registry twins. Other data collection efforts have focused on specific sets of twin pairs and conducted detailed clinical or laboratory testing.


Genders Eligible for Study:   Male
Accepts Healthy Volunteers:   No
Sampling Method:   Non-Probability Sample
Study Population

All subjects are members of the Vietnam Era Twin Registry, and are males born between 1939-1957.


Inclusion Criteria:

  • All twins who are currently active in the VET Registry will be invited to participate in CSP #569.

Exclusion Criteria:

  • Unable or unwilling to provide informed consent
  Contacts and Locations
Choosing to participate in a study is an important personal decision. Talk with your doctor and family members or friends about deciding to join a study. To learn more about this study, you or your doctor may contact the study research staff using the Contacts provided below. For general information, see Learn About Clinical Studies.

Please refer to this study by its identifier: NCT01175629

United States, Washington
VA Puget Sound Health Care System
Seattle, Washington, United States, 98101
Sponsors and Collaborators
Study Chair: Jack H Goldberg, PhD MA BA VA Puget Sound Health Care System, Seattle
Study Chair: Kathryn M. Magruder, PhD MPH BA Ralph H Johnson VA Medical Center, Charleston
  More Information

Responsible Party: Department of Veterans Affairs Identifier: NCT01175629     History of Changes
Other Study ID Numbers: 569
Study First Received: August 3, 2010
Last Updated: June 30, 2014
Health Authority: United States: Federal Government

Keywords provided by Department of Veterans Affairs:
Stress Disorders, Post-Traumatic
Cardiovascular Disease
Depressive Disorder
Behavioral Symptoms
Metabolic Diseases
Mental Disorders
Anxiety Disorders

Additional relevant MeSH terms:
Cardiovascular Diseases
Stress Disorders, Post-Traumatic
Stress Disorders, Traumatic
Anxiety Disorders
Mental Disorders processed this record on August 27, 2015