Treatment of Acute Stroke With Cromolyn(Single Dose)
Recruitment status was: Not yet recruiting
Mastocytes were proven to have a central rule in their development of the lipoid plaque of the vascular system. Mastocytes also has an important role in the stabilisation of the plaque in the building of the brain barrier. Different animal studies show that the inhibition of the mastocyte activity decreases significantly the risk of secondary bleeding post ischaemic stroke.It was also shown that post stroke inflammation process was also blocked by the inhibition of mastocytes.Other studies showed up to 100% decrease in the brain barrier disruption and post stroke oedema, after treatment with mastocyte inhibitors.
Cromolyn is a synthetic drug which has an anti-allergic effect by inhibition of the mastocytes. This drug is a well known,safe drug and is the main sub-substance that was used in the previously mentioned studies.
|Study Design:||Intervention Model: Parallel Assignment|
Placebo Comparator: sugar pill
sugar pill dissolved in water to be given 4 times a day 30 minutes prior to meals
Drug: sugar pill
sugar pill Dissolved in water taken 4 times daily 30 minutes prior to meals
Active Comparator: Cromolyn
Cromolyn dose of 200mg(dissolved in water) will be given 4 times a day(30 minutes before a meal)
Cromolyn 200mg (dissolved in water) given 4 times a day
Please refer to this study by its ClinicalTrials.gov identifier: NCT01175525
|Edith wolfson medical Center|
|Holon, Israel, 58100|
|Principal Investigator:||Yair Lampl, Neurologist||Wolfson Medical Center|