Assessment of Transcutaneous Oxygen Tension/Oxygen Challenge Test in Intensive Care Unit (ICU) Patients (ICUPtO2OCT)
Recruitment status was: Recruiting
The lack of subcutaneous partial pressure of oxygen (PO2) rise in response to high fraction of inspired oxygen (FiO2), called the "oxygen challenge test (OCT)", was associated with higher morbidity and mortality in human subjects. Patients had negative O2 challenge test results, indicating that flow-dependent O2 consumption might have been present. Recent reports using the noninvasive transcutaneous PO2 (PtO2) and transcutaneous partial pressure of carbon dioxide probes have observed a relationship between low oxygen challenge test values to mortality and organ failure. The OCT values provides an accessible noninvasive method of detecting early shock.
To date,these studies of OCT in the ICU patients are rarely. No one has quantified OCT to CI, DO2I、ScvO2.
This study explored:
- relationship between patient factors, hemodynamic variables, PtO2, and OCT to mortality;
- relationship between PtO2 index, tissue oxygen index, oxygen Challenge index to CI, DO2, ScvO2.
|Study Design:||Observational Model: Cohort
Time Perspective: Prospective
|Official Title:||Assessment of Transcutaneous Oxygen Tension and Oxygen Challenge Test in Adult Intensive Care Patients|
- ICU mortality [ Time Frame: 28 day after enrollmented ] [ Designated as safety issue: Yes ]
- hospital mortality [ Time Frame: 28 day after enrollmented ] [ Designated as safety issue: Yes ]
|Study Start Date:||September 2009|
|Estimated Study Completion Date:||October 2010|
|Estimated Primary Completion Date:||October 2010 (Final data collection date for primary outcome measure)|
PtO2 index = PtO2/PaO2；tissue oxygen index=PtO2/FiO2；
5min OCT value = challenged 5minPtO2 - PtO2baseline；
10min OCT value= challenged 10minPtO2- PtO2baseline；
oxygen challenge index = （10minPtO2- PtO2baseline）/(10minPaO2-PaO2baseline)
Please refer to this study by its ClinicalTrials.gov identifier: NCT01174966
|Peking Union Medical College Hospital|
|Beijing, Beijing, China, 100730|
|Principal Investigator:||dawei liu, MD||Peking Union Medical College Hospital|