Assessment of Transcutaneous Oxygen Tension/Oxygen Challenge Test in Intensive Care Unit (ICU) Patients (ICUPtO2OCT)

The safety and scientific validity of this study is the responsibility of the study sponsor and investigators. Listing a study does not mean it has been evaluated by the U.S. Federal Government. Read our disclaimer for details. Identifier: NCT01174966
Recruitment Status : Unknown
Verified August 2010 by gwcmc.
Recruitment status was:  Recruiting
First Posted : August 4, 2010
Last Update Posted : August 4, 2010
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Brief Summary:

The lack of subcutaneous partial pressure of oxygen (PO2) rise in response to high fraction of inspired oxygen (FiO2), called the "oxygen challenge test (OCT)", was associated with higher morbidity and mortality in human subjects. Patients had negative O2 challenge test results, indicating that flow-dependent O2 consumption might have been present. Recent reports using the noninvasive transcutaneous PO2 (PtO2) and transcutaneous partial pressure of carbon dioxide probes have observed a relationship between low oxygen challenge test values to mortality and organ failure. The OCT values provides an accessible noninvasive method of detecting early shock.

To date,these studies of OCT in the ICU patients are rarely. No one has quantified OCT to CI, DO2I、ScvO2.

This study explored:

  1. relationship between patient factors, hemodynamic variables, PtO2, and OCT to mortality;
  2. relationship between PtO2 index, tissue oxygen index, oxygen Challenge index to CI, DO2, ScvO2.

Condition or disease
Sepsis Shock

Detailed Description:

PtO2 index = PtO2/PaO2;tissue oxygen index=PtO2/FiO2;

5min OCT value = challenged 5minPtO2 - PtO2baseline;

10min OCT value= challenged 10minPtO2- PtO2baseline;

oxygen challenge index = (10minPtO2- PtO2baseline)/(10minPaO2-PaO2baseline)

Study Type : Observational
Estimated Enrollment : 60 participants
Observational Model: Cohort
Time Perspective: Prospective
Official Title: Assessment of Transcutaneous Oxygen Tension and Oxygen Challenge Test in Adult Intensive Care Patients
Study Start Date : September 2009
Estimated Primary Completion Date : October 2010
Estimated Study Completion Date : October 2010

Resource links provided by the National Library of Medicine

MedlinePlus related topics: Oxygen Therapy

Survivor Nonsurvivor

Primary Outcome Measures :
  1. ICU mortality [ Time Frame: 28 day after enrollmented ]

Secondary Outcome Measures :
  1. hospital mortality [ Time Frame: 28 day after enrollmented ]

Information from the National Library of Medicine

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Ages Eligible for Study:   18 Years to 95 Years   (Adult, Older Adult)
Sexes Eligible for Study:   All
Accepts Healthy Volunteers:   No
Sampling Method:   Probability Sample
Study Population
The subjects were sequentially admitted to the Department of Critical Care department of Peking Union Medical College Hospital from sept. of 2009 till the end of this study.

Inclusion Criteria:

  • 18 years of age or older
  • Requiring a artery catheters, and pulmonary artery catheters or PiCCO-plus or central venous catheters
  • FiO2<80% and SpO2>92%
  • Consent informed

Exclusion Criteria:

  • Not expected to live

Information from the National Library of Medicine

To learn more about this study, you or your doctor may contact the study research staff using the contact information provided by the sponsor.

Please refer to this study by its identifier (NCT number): NCT01174966

Contact: dawei liu, MD 010-65296091
Contact: huaiwu he 010-65296094

China, Beijing
Peking Union Medical College Hospital Recruiting
Beijing, Beijing, China, 100730
Contact: dawei liu, MD    010-65296091   
Contact: huaiwu he    010-65296094   
Sub-Investigator: huaiwu he         
Sponsors and Collaborators
Principal Investigator: dawei liu, MD gwcmc