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Effects of Pursed-lip Breathing on Exercise Tolerance and Dynamic Hyperinflation in COPD

This study has been completed.
Information provided by:
Universidade Federal do Rio de Janeiro Identifier:
First received: July 19, 2010
Last updated: July 30, 2010
Last verified: August 2008

Pursed-lip breathing (PLB) has been advocated to reduce respiratory rate and improve oxygen saturation in patients with chronic obstructive pulmonary disease (COPD) at rest. Although PLB is a strategy that potentially reduces expiratory flow limitation, there are only few studies addressing its effects on exercise.

This study aimed to assess the ability of PLB to change the breathing pattern, degree of dynamic hyperinflation (DH) and arterial oxygenation in COPD patients during exercise. Exercise tolerance was evaluated by endurance time and respiratory mechanics was evaluated by forced oscillation technique.

Condition Intervention
Chronic Obstructive Pulmonary Disease
Behavioral: Pursed-lip breathing
Behavioral: Normal Breathing

Study Type: Interventional
Study Design: Allocation: Randomized
Intervention Model: Crossover Assignment
Masking: Single Blind (Outcomes Assessor)
Primary Purpose: Treatment
Official Title: Effects of Pursed-lip Breathing on Exercise Tolerance and Dynamic Hyperinflation in Chronic Obstructive Pulmonary Disease

Resource links provided by NLM:

Further study details as provided by Universidade Federal do Rio de Janeiro:

Primary Outcome Measures:
  • Endurance time [ Time Frame: within the first 01 hour ]

Secondary Outcome Measures:
  • inspiratory capacity [ Time Frame: within the first 01 hour ]
  • oxygen saturation [ Time Frame: within the first 01 hour ]
  • dyspnea [ Time Frame: within the first 01 hour ]
  • forced oscillation variables [ Time Frame: within the first 01 hour ]

Enrollment: 40
Study Start Date: March 2007
Study Completion Date: October 2009
Primary Completion Date: October 2009 (Final data collection date for primary outcome measure)
Arms Assigned Interventions
Experimental: Pursed-lip Breathing Behavioral: Pursed-lip breathing
Pursed-lip breathing involves a nasal inspiration followed by expiratory blowing against partially closed lips, avoiding forceful exhalation.
Behavioral: Normal Breathing


Ages Eligible for Study:   40 Years and older   (Adult, Senior)
Sexes Eligible for Study:   All
Accepts Healthy Volunteers:   No

Inclusion Criteria:

  • Clinical diagnosis of chronic obstructive pulmonary disease (COPD)
  • Regular treatment at Clementino Fraga Filho University Hospital (UFRJ)

Exclusion Criteria:

  • Exacerbation in the preceding 4 weeks
  • SpO2<85% at peak exercise
  • Other diseases that may contribute to dyspnea and exercise intolerance
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Please refer to this study by its identifier: NCT01173328

Clementino Fraga Filho University Hospital
Rio de Janeiro, Brazil
Sponsors and Collaborators
Universidade Federal do Rio de Janeiro
Study Director: Fernando S Guimarães, PhD Universidade Federal do Rio de Janeiro
  More Information

Responsible Party: Leandro Ferracini Cabral, Universidade Federal de Juiz de Fora Identifier: NCT01173328     History of Changes
Other Study ID Numbers: CEP/HUCFF/UFRJ 187/07
Study First Received: July 19, 2010
Last Updated: July 30, 2010

Keywords provided by Universidade Federal do Rio de Janeiro:
exercise tolerance
dynamic hyperinflation
respiratory mechanics

Additional relevant MeSH terms:
Lung Diseases
Lung Diseases, Obstructive
Pulmonary Disease, Chronic Obstructive
Respiratory Tract Diseases processed this record on April 28, 2017