Predicting Hypotension During Dialysis in the ICU
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|ClinicalTrials.gov Identifier: NCT01171352|
Recruitment Status : Unknown
Verified July 2010 by Oregon Health and Science University.
Recruitment status was: Recruiting
First Posted : July 28, 2010
Last Update Posted : March 4, 2011
|Condition or disease||Intervention/treatment|
|Peridialytic Hypotension||Procedure: Transpulmonary Thermodilution|
|Study Type :||Observational|
|Estimated Enrollment :||120 participants|
|Official Title:||Predicting Hypotension During Dialysis in the ICU|
|Study Start Date :||July 2010|
|Estimated Primary Completion Date :||July 2011|
|Estimated Study Completion Date :||July 2011|
ICU Dialysis Patients
Any patient 18 years and older who is admitted to the OHSU Hospitals ICUs with ARF, or End Stage Renal Disease (ESRD) for a diagnosis other than hyperkalemia, as the sole determinant for that level of care, will be invited to participate. The patient must have acute or chronic needs for dialytic support during their ICU stay.
Procedure: Transpulmonary Thermodilution
A PiCCO femoral catheter will be placed and PiCCO parameters will be obtained using transpulmonary thermodilution after continuous dialysis is ordered or just prior to initiation of intermittent dialysis, hourly until either completion of intermittent dialysis or 8 hours of continuous dialysis is completed.
- hypotensive episode [ Time Frame: during or within one hour post dialysis ]A mean arterial pressure of <60 mmHg, a 15% decrease from baseline systolic blood pressure at the start of the dialysis treatment regardless of modality, the need for fluid bolusing >7 mL/kg body weight, or initiation or increase of vasopressor medication in order to maintain MAP >60 mmHg.
- fluid removal tolerance [ Time Frame: during the 4 hours following parameter measurement in dialysis ]Parameters measured will be examined to discriminate between patients that will tolerate fluid removal (UF) during the following 4 hours of dialysis if UF is ordered by physician (no hypotensive events with > 500 mL fluid removal) from those that won't
- predicted volume of fluid that can be removed without hypotensive events [ Time Frame: during dialysis ]Parameters measured will be examined to see if they can predict the volume of fluid successfully removed without hypotensive events
- mortality in the ICU [ Time Frame: duration of ICU stay ]
- All cause mortality [ Time Frame: 30 days ]
- Length of stay in ICU [ Time Frame: ICU stay duration ]
- Length of stay in hospital [ Time Frame: duration of hospital stay ]
To learn more about this study, you or your doctor may contact the study research staff using the contact information provided by the sponsor.
Please refer to this study by its ClinicalTrials.gov identifier (NCT number): NCT01171352
|Contact: Samantha S Ruimy, MSISemail@example.com|
|United States, Oregon|
|Oregon Health and Science University||Recruiting|
|Portland, Oregon, United States, 97239|
|Contact: Charles R Phillips, MD 503-494-2465 firstname.lastname@example.org|
|Contact: Suppriya Maddirala, MD 5034947653 email@example.com|
|Principal Investigator: Charles R Phillips, MD|
|Sub-Investigator: Suppriya Maddirala, MD|
|Sub-Investigator: Akram Khan, MD|
|Sub-Investigator: Ryan Griffiths, MD|
|Principal Investigator:||Charles R Phillips, MD||Oregon Health and Science University|