Left Atrial Distensibility to Predict Prognosis in Consecutive Patients
|ClinicalTrials.gov Identifier: NCT01171040|
Recruitment Status : Unknown
Verified July 2009 by Kaohsiung Veterans General Hospital..
Recruitment status was: Recruiting
First Posted : July 28, 2010
Last Update Posted : March 8, 2011
|Condition or disease||Intervention/treatment|
|Heart Failure Atrial Fibrillation Stroke||Other: Echocardiography, including the measurements of left atrial (LA) distensibility|
Show Detailed Description
|Study Type :||Observational|
|Estimated Enrollment :||2000 participants|
|Official Title:||Studies on Assessment of Left Atrial Distensibility to Predict Late Prognosis in Consecutive Patients Received Echocardiographic Examination|
|Study Start Date :||July 2009|
|Estimated Primary Completion Date :||July 2011|
|Estimated Study Completion Date :||July 2012|
Consecutive patients received echocardiographic examinations
Consecutive patients received echocardiography are willing to participate in this study.
Other: Echocardiography, including the measurements of left atrial (LA) distensibility
The LA volumes were measured at three points: 1) immediately before the mitral valve opening (maximal LV volume or Volmax); 2) at onset of the P-wave on electrocardiography (pre-atrial contraction volume or Volp); and 3) at mitral valve closure (minimal LV volume or Volmin). The LA distensibility was calculated as (Volmax - Volmin)x 100% / Volmin. The LA ejection fraction was calculated as (Volp - Volmin)x 100% / Volp. In all patients, LA volumes were indexed to body surface area (BSA).
- All cause mortality [ Time Frame: 2 years ]All cause mortality and heart failure with re-hospitalization were defined as hard cardiovascular event.
- Heart failure with hospitalization [ Time Frame: 2 years ]Heart failure with re-hospitalization is documented by at least one of the following: worse exercise tolerance and respiratory distress with NYHA class III or IV symptoms, presence of pulmonary rales, or chest radiography showing pulmonary congestion, which needs an augmented decongestive regimen with oral or intravenous medications during an in-hospital stay.
- Atrial fibrillation [ Time Frame: 2 years ]Enrolled patients with intermittent tachycardia will receive Holter's EKG. Any events of atrial fibrillation documented by EKG or Holter, either paroxysmal or persistent, are accounted.
- Stroke [ Time Frame: 2 years ]Stroke is defined as a sudden onset of focal neurological deficit more than 24 hours and confirmed by brain computed tomography or magnetic resonance imaging. Trans-esophageal echocardiography is suggested to clarify whether cardiogenic or not for all patients with stroke.
Please refer to this study by its ClinicalTrials.gov identifier (NCT number): NCT01171040
|Contact: Jong-Khing Huang, MD||886-7-3422121 ext firstname.lastname@example.org|
|Kaohsiung Veterans General Hospital||Recruiting|
|Kaohsiung, Taiwan, 886|
|Contact: Jong-Khing Huang, MD 886-7-3422121 ext 1518 email@example.com|
|Contact: Shih-Hung Hsiao, MD 886-7-3422121 ext 2011 firstname.lastname@example.org|
|Principal Investigator: Jong-Khing Huang, MD|
|Principal Investigator:||Shih-Hung Hsiao, MD||Cardiovascular Center, Department of Internal Medicine, Kaohsiung Veterans General Hospital|