320 Multidetector Computed Tomography Prior to Coronary Artery Bypass Surgery

The safety and scientific validity of this study is the responsibility of the study sponsor and investigators. Listing a study does not mean it has been evaluated by the U.S. Federal Government. Read our disclaimer for details. Identifier: NCT01169948
Recruitment Status : Withdrawn (Not funded.)
First Posted : July 26, 2010
Last Update Posted : March 14, 2013
Information provided by (Responsible Party):
University of Edinburgh

Brief Summary:
Recent advances in technology have resulted in the development of scanners that can n image the heart arteries within 10 to 20 minutes but without the need for admission to hospital or insertion of catheters. This means that coronary heart disease may be more readily identified (or ruled out) and allow better diagnosis and treatment of patients with symptoms suggesting coronary heart disease. Here, we propose to assess the latest and most powerful scanners to see if it can accurately diagnose the extent of coronary artery disease and facilitate the planning of heart surgery.

Condition or disease Intervention/treatment
Coronary Disease Radiation: Computed tomography scan

Study Type : Observational
Actual Enrollment : 0 participants
Observational Model: Case-Only
Time Perspective: Cross-Sectional
Official Title: 320 Multidetector Computed Tomography in the Preoperative Assessment for Coronary Artery Bypass Graft Surgery
Study Start Date : June 2010

Resource links provided by the National Library of Medicine

Group/Cohort Intervention/treatment
Patients awaiting cardiac surgery Radiation: Computed tomography scan
Computed tomography will be performed using a 320 multidetector computed tomography scanner and may include coronary calcium score, coronary angiography and myocardial perfusion scanning.

Primary Outcome Measures :
  1. Coronary artery stenosis defined qualitatively by trained observers and quantitatively by computer software [ Time Frame: 1 month ]

Secondary Outcome Measures :
  1. Myocardial perfusion defects defined qualitatively by trained observers and quantitatively by computer software [ Time Frame: 1 month ]

Information from the National Library of Medicine

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Ages Eligible for Study:   18 Years and older   (Adult, Older Adult)
Sexes Eligible for Study:   All
Accepts Healthy Volunteers:   No
Sampling Method:   Non-Probability Sample
Study Population
Outpatients awaiting cardiac surgery.

Inclusion Criteria:

  • patients who have undergone conventional coronary angiography and have been referred for coronary artery bypass surgery or valve replacement

Exclusion Criteria:

  • age less than 18
  • pregnancy or breast feeding
  • inability to undergo computed tomography scanning
  • inability to give informed consent
  • severe renal failure (serum creatinine >250umol/l or estimated glomerular filtration rate <15ml/min)
  • known allergy to iodinated contrast

Information from the National Library of Medicine

To learn more about this study, you or your doctor may contact the study research staff using the contact information provided by the sponsor.

Please refer to this study by its identifier (NCT number): NCT01169948

United Kingdom
Royal Infirmary of Edinburgh
Edinburgh, Scotland, United Kingdom, EH16 4SA
Sponsors and Collaborators
University of Edinburgh
Principal Investigator: David E Newby, PhD BM DM University of Edinburgh

Responsible Party: University of Edinburgh Identifier: NCT01169948     History of Changes
Other Study ID Numbers: 2009/R/CAR/17
First Posted: July 26, 2010    Key Record Dates
Last Update Posted: March 14, 2013
Last Verified: March 2013

Keywords provided by University of Edinburgh:
Coronary disease
Coronary artery bypass
Cardiac surgery
Computed tomography
Coronary angiography

Additional relevant MeSH terms:
Coronary Disease
Coronary Artery Disease
Myocardial Ischemia
Heart Diseases
Cardiovascular Diseases
Vascular Diseases
Arterial Occlusive Diseases