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Regulation of Endothelial Progenitor Cells by Short-Term Exercise (EPC-Ex)

This study is ongoing, but not recruiting participants.
Sponsor:
ClinicalTrials.gov Identifier:
NCT01169831
First Posted: July 26, 2010
Last Update Posted: February 28, 2017
The safety and scientific validity of this study is the responsibility of the study sponsor and investigators. Listing a study does not mean it has been evaluated by the U.S. Federal Government. Read our disclaimer for details.
Collaborator:
Baltimore VA Medical Center
Information provided by (Responsible Party):
Steven J. Prior, Ph.D., University of Maryland
  Purpose
Endothelial Progenitor Cells (EPCs) are circulating cells released from bone marrow which are important for maintaining cardiovascular health. The prevalence of cardiovascular disease in older adults is associated with reduced circulating EPC numbers. Studies have shown reduced EPC number and function in old vs. young individuals, and endurance exercise training increases EPC number and function in young adults. Oxidative stress adversely affects endothelial cells and preliminary evidence indicates that oxidative stress negatively affects EPC function. Conversely, regular exercise reduces markers of oxidative stress and may enhance EPC function in older adults. The investigators hypothesize that older endurance-trained athletes and matched sedentary individuals will have markedly divergent EPC function and that altering the physical activity levels of both groups will move them to intermediate points between these two extremes. The investigators also propose that the investigators can "mimic" the effect of exercise training on EPC function in cell culture by altering intracellular levels of a key enzyme and a signaling molecule which the investigators have shown to regulate EPC function with respect to exercise training in young individuals.

Condition Intervention
Aging Exercise Cardiovascular Disease Other: Exercise Training Other: Exercise Cessation

Study Type: Interventional
Study Design: Allocation: Non-Randomized
Intervention Model: Single Group Assignment
Masking: None (Open Label)
Primary Purpose: Other
Official Title: Regulation of Endothelial Progenitor Cells by Short-Term Exercise

Resource links provided by NLM:


Further study details as provided by Steven J. Prior, Ph.D., University of Maryland:

Primary Outcome Measures:
  • Baseline Endothelial progenitor cell number [ Time Frame: Day 1 ]
  • Final Endothelial Progenitor Cell Number [ Time Frame: Day 15 ]

Secondary Outcome Measures:
  • Baseline Endothelial Reactivity [ Time Frame: Day 1 ]
  • Final Endothelial Reactivity [ Time Frame: Day 15 ]

Estimated Enrollment: 60
Study Start Date: July 2011
Estimated Study Completion Date: November 2018
Primary Completion Date: November 2014 (Final data collection date for primary outcome measure)
Arms Assigned Interventions
Experimental: Sedentary Older Adults Other: Exercise Training
2 weeks of daily aerobic exercise training
Experimental: Older Endurance Athletes Other: Exercise Cessation
Stopping all exercise for 2 weeks

  Eligibility

Information from the National Library of Medicine

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Ages Eligible for Study:   50 Years to 80 Years   (Adult, Senior)
Sexes Eligible for Study:   All
Accepts Healthy Volunteers:   Yes
Criteria

Inclusion Criteria:

  • 50-80 years of age, BMI = 18-35 kg/m2, non-smoking, women must be postmenopausal

Exclusion Criteria:

  • history of cardiovascular/cerebrovascular disease, diabetes, cancer, renal, liver disease, HIV; uncontrolled hyperlipidemia/hypertension
  Contacts and Locations
Information from the National Library of Medicine

To learn more about this study, you or your doctor may contact the study research staff using the contact information provided by the sponsor.

Please refer to this study by its ClinicalTrials.gov identifier (NCT number): NCT01169831


Locations
United States, Maryland
University of Maryland, Baltimore & Baltimore VA Medical Center
Baltimore, Maryland, United States, 21201
Sponsors and Collaborators
University of Maryland
Baltimore VA Medical Center
Investigators
Principal Investigator: Steven J Prior, Ph.D. University of Maryland
  More Information

Additional Information:
Responsible Party: Steven J. Prior, Ph.D., Assistant Professor, University of Maryland
ClinicalTrials.gov Identifier: NCT01169831     History of Changes
Other Study ID Numbers: HP-00045413
First Submitted: July 23, 2010
First Posted: July 26, 2010
Last Update Posted: February 28, 2017
Last Verified: February 2017

Additional relevant MeSH terms:
Cardiovascular Diseases