A Study Comparing the Safety, Tolerance, and Efficacy of Various Doses of SK-0403 Versus Placebo and Sitagliptin 100 mg in Patients Not Well-Controlled on Metformin Therapy
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A Multicenter, Randomized, Parallel-Group, Double-Blind, Placebo Controlled Phase 2 Dose Finding Study Comparing the Safety, Tolerance, and Efficacy of Various Doses of SK-0403 Versus Placebo and Sitagliptin 100 mg in Patients Not Well-Controlled on Metformin Therapy
Study Start Date :
Actual Primary Completion Date :
Actual Study Completion Date :
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Ages Eligible for Study:
18 Years to 75 Years (Adult, Senior)
Sexes Eligible for Study:
Accepts Healthy Volunteers:
Male and female subjects with type 2 diabetes between 18 and 75 years of age, inclusive
Screening HbA1c between 7.0% to 10.0% for metformin stable subjects, 6.5% to 9.0% for subjects on metformin and 1 other antidiabetic agent (excluding thiazolidinediones, insulin, or incretin therapies [DPP-4 inhibitors and GLP-1 analogues]), or 7.5% to 11.0% for subjects on no antidiabetic medication or, if taking metformin, not on a stable dose of 1500 mg/day or maximum tolerated dose.
No antidiabetic medication other than metformin for 3 months prior to randomization.
Fasting plasma glucose less than 270 mg/dL (15 mmol/L) at screening.
Body mass index between 20 kg/m2 and 45 kg/m2 inclusive at screening.
History of type 1 diabetes.
Received treatment with insulin within 30 days of the screening visit or for more than 1 week within 3 months of the screening visit.
Use of 3 or more oral antidiabetic medications at the time of the screening visit.